{"id":42072,"date":"2025-09-03T12:47:40","date_gmt":"2025-09-03T10:47:40","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/03\/f4-80-the-plasma-membrane-antigen-of-mouse-macrophages-an-historic-journeysiamon-gordon-on-3-de-september-de-2025-at-1000\/"},"modified":"2025-09-03T12:47:40","modified_gmt":"2025-09-03T10:47:40","slug":"f4-80-the-plasma-membrane-antigen-of-mouse-macrophages-an-historic-journeysiamon-gordon-on-3-de-september-de-2025-at-1000","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/03\/f4-80-the-plasma-membrane-antigen-of-mouse-macrophages-an-historic-journeysiamon-gordon-on-3-de-september-de-2025-at-1000\/","title":{"rendered":"F4\/80, the Plasma Membrane Antigen of Mouse Macrophages, an historic journey\u200bSiamon Gordon on 3 de September de 2025 at 10:00"},"content":{"rendered":"
\n

J Leukoc Biol<\/b>. 2025 Sep 3:qiaf126. doi: 10.1093\/jleuko\/qiaf126. Online ahead of print.<\/p>\n

ABSTRACT<\/b><\/p>\n

As its discovery nears a half century, the widespread use of F4\/80 antigen as a differentiation marker of tissue macrophages of the mouse, continues to raise questions in and beyond experimental cellular immunology. Its structure as a 7 transmembrane G Protein Coupled Receptor initiated the discovery of a diverse family of plasma membrane receptors. This review will trace milestones of research into the expression of F4\/80, also known as Emr1, its value as a marker in formulation of the Mononuclear Phagocyte System and its function in a model of peripheral immune tolerance in the anterior chamber of the eye. Human EMR1 is closely related to a primate-restricted myeloid mechanoreceptor, EMR2, with a novel autocatalytic activation mechanism. We describe their relation to structurally related members of the group E adhesion GPCR subfamily and their contributions to homeostatic systems of the body through local plasma membrane cellular interactions.<\/p>\n

PMID:40898835<\/a> | DOI:10.1093\/jleuko\/qiaf126<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Leukoc Biol. 2025 Sep 3:qiaf126. doi: 10.1093\/jleuko\/qiaf126. Online ahead of print. ABSTRACT As its discovery nears a half century, the widespread use of F4\/80 antigen as a differentiation marker of tissue macrophages of the mouse, continues to raise questions in and beyond experimental cellular immunology. Its structure as a 7 transmembrane G Protein Coupled … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-42072","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42072","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=42072"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42072\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=42072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=42072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=42072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}