{"id":42113,"date":"2025-09-04T00:47:51","date_gmt":"2025-09-03T22:47:51","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/04\/flt3l-neutralization-reduces-dendritic-cell-numbers-t-cell-activation-and-salivary-gland-lymphocyte-infiltration-in-the-nod-h2h4-sjogrens-mouse-model\/"},"modified":"2025-09-04T00:47:51","modified_gmt":"2025-09-03T22:47:51","slug":"flt3l-neutralization-reduces-dendritic-cell-numbers-t-cell-activation-and-salivary-gland-lymphocyte-infiltration-in-the-nod-h2h4-sjogrens-mouse-model","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/04\/flt3l-neutralization-reduces-dendritic-cell-numbers-t-cell-activation-and-salivary-gland-lymphocyte-infiltration-in-the-nod-h2h4-sjogrens-mouse-model\/","title":{"rendered":"FLT3L neutralization reduces dendritic cell numbers, T Cell activation, and salivary gland lymphocyte infiltration in the NOD.H2h4 Sj\u00f6gren&#8217;s mouse model"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Sep 3:vkaf220. doi: 10.1093\/jimmun\/vkaf220. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The Feline McDonough sarcoma-like tyrosine kinase 3 (FLT3)\/FLT3 ligand (FLT3L) pathway is associated with pathogenesis of several autoimmune diseases, including Sj\u00f6gren&#8217;s. Inflammatory signals increase FLT3L levels; FLT3L signaling promotes further inflammation through the differentiation, function, and survival of immune cells, including dendritic cells (DCs), monocytes, and B cells. Patients with Sj\u00f6gren&#8217;s have elevated FLT3L levels, increased infiltration of DCs, macrophages, and B cells into salivary glands and tertiary lymphoid structures (TLS). We hypothesized that therapeutically neutralizing FLT3L may reduce inflammatory manifestations in the NOD.H2h4 spontaneous Sj\u00f6gren&#8217;s mouse model. Female mice aged 15 to 17 wk, an age at which features of Sj\u00f6gren&#8217;s have developed, were administered an anti-mouse FLT3L monoclonal antibody or isotype control for 8 wk. Compared with control, anti-FLT3L antibody treatment significantly reduced free serum FLT3L, splenic DC numbers, T cell activation, and salivary gland TLS (P &lt; 0.05 for all). Neutralizing FLT3L may effectively treat Sj\u00f6gren&#8217;s and other FLT3L-associated autoimmune diseases.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40902038\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250903184748&amp;v=2.18.0.post9+e462414\">40902038<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf220\">10.1093\/jimmun\/vkaf220<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Sep 3:vkaf220. doi: 10.1093\/jimmun\/vkaf220. Online ahead of print. ABSTRACT The Feline McDonough sarcoma-like tyrosine kinase 3 (FLT3)\/FLT3 ligand (FLT3L) pathway is associated with pathogenesis of several autoimmune diseases, including Sj\u00f6gren&#8217;s. Inflammatory signals increase FLT3L levels; FLT3L signaling promotes further inflammation through the differentiation, function, and survival of immune cells, including dendritic cells &#8230; <a title=\"FLT3L neutralization reduces dendritic cell numbers, T Cell activation, and salivary gland lymphocyte infiltration in the NOD.H2h4 Sj\u00f6gren&#8217;s mouse model\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/04\/flt3l-neutralization-reduces-dendritic-cell-numbers-t-cell-activation-and-salivary-gland-lymphocyte-infiltration-in-the-nod-h2h4-sjogrens-mouse-model\/\" aria-label=\"Read more about FLT3L neutralization reduces dendritic cell numbers, T Cell activation, and salivary gland lymphocyte infiltration in the NOD.H2h4 Sj\u00f6gren&#8217;s mouse model\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-42113","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=42113"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42113\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=42113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=42113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=42113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}