{"id":42182,"date":"2025-09-04T11:52:30","date_gmt":"2025-09-04T09:52:30","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/04\/perturbances-in-both-circulating-b-and-cd4-t-cells-discriminate-multiple-sclerosis-from-other-central-nervous-system-autoimmune-diseases-valuelaurens-bogers-jasper-rip-suzanne-c-frank\/"},"modified":"2025-09-04T11:52:30","modified_gmt":"2025-09-04T09:52:30","slug":"perturbances-in-both-circulating-b-and-cd4-t-cells-discriminate-multiple-sclerosis-from-other-central-nervous-system-autoimmune-diseases-valuelaurens-bogers-jasper-rip-suzanne-c-frank","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/04\/perturbances-in-both-circulating-b-and-cd4-t-cells-discriminate-multiple-sclerosis-from-other-central-nervous-system-autoimmune-diseases-valuelaurens-bogers-jasper-rip-suzanne-c-frank\/","title":{"rendered":"Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases. [[{&#8220;value&#8221;:&#8221;Laurens Bogers, \nJasper Rip, \nSuzanne C. Franken, \nKirsten L. Kuiper, \nAna M. Marques, \nAnnet F. Wierenga\u2010Wolf, \nMarie\u2010Jos\u00e9 Melief, \nCato E. A. Corsten, \nRomy A. M. Klein Kranenbarg, \nJanet de Beukelaar, \nIde Smets, \nBeatrijs H. Wokke, \nMaarten J. Titulaer, \nJoost Smolders, \nMarvin M. van Luijn&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/d0547afa-166f-4422-b83b-94c76f818d2a\/eji70049-gra-0001-m.png\" alt=\"Perturbances in Both Circulating B and CD4+ T Cells Discriminate Multiple Sclerosis from Other Central Nervous System Autoimmune Diseases\" \/><\/p>\n<p>Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4<sup>+<\/sup> T-cell frequencies were a disease-specific feature of MS, while reduced T-bet<sup>+<\/sup> and CXCR3<sup>+<\/sup> B-cell levels were associated with progressive disease.<\/p>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Using spectral flow cytometry, we analyzed circulating lymphocyte subsets in treatment-naive individuals with multiple sclerosis (MS) and other central nervous system autoimmune diseases (CNS AIDs). Elevated B-cell and CD4+ T-cell frequencies were a disease-specific feature of MS, while reduced T-bet+ and CXCR3+ B-cell levels were associated with progressive disease.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-42182","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=42182"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42182\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=42182"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=42182"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=42182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}