{"id":42842,"date":"2025-09-10T10:50:21","date_gmt":"2025-09-10T08:50:21","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/10\/cd4-t-cells-acquire-innate-capability-upon-classical-t-cell-activation-valuenima-yassini-eva-goljat-camilla-panetti-matthias-rath-nicole-joller\/"},"modified":"2025-09-10T10:50:21","modified_gmt":"2025-09-10T08:50:21","slug":"cd4-t-cells-acquire-innate-capability-upon-classical-t-cell-activation-valuenima-yassini-eva-goljat-camilla-panetti-matthias-rath-nicole-joller","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/10\/cd4-t-cells-acquire-innate-capability-upon-classical-t-cell-activation-valuenima-yassini-eva-goljat-camilla-panetti-matthias-rath-nicole-joller\/","title":{"rendered":"CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation. [[{&#8220;value&#8221;:&#8221;Nima Yassini, \nEva Goljat, \nCamilla Panetti, \nMatthias Rath, \nNicole Joller&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/7184d16d-f252-4284-88ce-6123496b1a5c\/eji70054-gra-0001-m.png\" alt=\"CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation\" \/><\/p>\n<p>The innate actions of the immune system allow for a rapid response to potential threats. Here we show that upon classical T cell activation, both murine and human adaptive immune cells can acquire innate capabilities allowing them to respond to cytokines in a TCR independent manner.<\/p>\n<p><\/p>\n<h2>ABSTRACT<\/h2>\n<p>Memory T cells, a sizable compartment of the mature immune system, enable enhanced responses upon re-infection with the same pathogen. We have recently shown that virus-experienced innate acting T (T<sub>IA<\/sub>) cells can modulate infectious or autoimmune diseases through TCR-independent IFN-\u03b3 production. However, how these cells arise remains unclear. Here, we show that CD4 T<sub>IA<\/sub> cells are present in various disease settings hinting towards a disease-agnostic nature. TCR stimulation and CD28 co-stimulation are sufficient to induce na\u00efve murine and human CD4 T cells to become capable of cytokine-mediated, TCR-independent IFN-\u03b3 responses. In true T<sub>IA<\/sub> fashion, adoptive transfer of in vitro-induced T<sub>IA<\/sub> cells in mice yielded a TCR-independent IFN-\u03b3 response during the innate phase of a <i>Legionella pneumophila<\/i> infection. Our data thus shows that CD4 T<sub>IA<\/sub> cells are more ubiquitous than anticipated and could therefore be involved in more settings than expected.<\/p>","protected":false},"excerpt":{"rendered":"<p>The innate actions of the immune system allow for a rapid response to potential threats. Here we show that upon classical T cell activation, both murine and human adaptive immune cells can acquire innate capabilities allowing them to respond to cytokines in a TCR independent manner. ABSTRACT Memory T cells, a sizable compartment of the &#8230; <a title=\"CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation. [[{&#8220;value&#8221;:&#8221;Nima Yassini, \nEva Goljat, \nCamilla Panetti, \nMatthias Rath, \nNicole Joller&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/10\/cd4-t-cells-acquire-innate-capability-upon-classical-t-cell-activation-valuenima-yassini-eva-goljat-camilla-panetti-matthias-rath-nicole-joller\/\" aria-label=\"Read more about CD4 T Cells Acquire Innate Capability Upon Classical T Cell Activation. [[{&#8220;value&#8221;:&#8221;Nima Yassini, \nEva Goljat, \nCamilla Panetti, \nMatthias Rath, \nNicole Joller&#8221;}]]\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-42842","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=42842"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/42842\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=42842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=42842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=42842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}