{"id":43098,"date":"2025-09-11T06:47:14","date_gmt":"2025-09-11T04:47:14","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/11\/uncovering-the-evolving-arms-race-between-host-immunity-and-hiv-1-young-hwan-song\/"},"modified":"2025-09-11T06:47:14","modified_gmt":"2025-09-11T04:47:14","slug":"uncovering-the-evolving-arms-race-between-host-immunity-and-hiv-1-young-hwan-song","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/11\/uncovering-the-evolving-arms-race-between-host-immunity-and-hiv-1-young-hwan-song\/","title":{"rendered":"Uncovering the evolving arms race between host immunity and HIV-1. Young-Hwan Song"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Sep 9:S1471-4906(25)00202-9. doi: 10.1016\/j.it.2025.08.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Despite an effective combination of antiretroviral therapy, HIV persists as a lifelong infection and global health threat. The human host equips restriction factors and interferon (IFN)-stimulated genes that target every step of the viral life cycle. However, HIV-1 has evolved a coordinated immune evasion strategy using a limited set of accessory proteins with distinct antagonistic functions. This functional division of labor allows HIV-1 to disable key immune pathways and ensure persistence. Here, we explore the molecular interplay between host defenses and HIV-1, organizing antiviral factors by viral life cycle stage. We further reframe viral immune evasion as a strategic division of labor among accessory proteins each adapted to target specific host defenses, offering insights for next-generation therapies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40930905\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250911004712&amp;v=2.18.0.post9+e462414\">40930905<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.08.004\">10.1016\/j.it.2025.08.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Sep 9:S1471-4906(25)00202-9. doi: 10.1016\/j.it.2025.08.004. Online ahead of print. ABSTRACT Despite an effective combination of antiretroviral therapy, HIV persists as a lifelong infection and global health threat. The human host equips restriction factors and interferon (IFN)-stimulated genes that target every step of the viral life cycle. However, HIV-1 has evolved a coordinated immune &#8230; <a title=\"Uncovering the evolving arms race between host immunity and HIV-1. Young-Hwan Song\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/11\/uncovering-the-evolving-arms-race-between-host-immunity-and-hiv-1-young-hwan-song\/\" aria-label=\"Read more about Uncovering the evolving arms race between host immunity and HIV-1. Young-Hwan Song\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-43098","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43098","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=43098"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43098\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=43098"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=43098"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=43098"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}