{"id":43346,"date":"2025-09-13T06:47:05","date_gmt":"2025-09-13T04:47:05","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/13\/skin-manifestations-of-sars-cov-2-infection-and-its-vaccination\/"},"modified":"2025-09-13T06:47:05","modified_gmt":"2025-09-13T04:47:05","slug":"skin-manifestations-of-sars-cov-2-infection-and-its-vaccination","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/13\/skin-manifestations-of-sars-cov-2-infection-and-its-vaccination\/","title":{"rendered":"Skin manifestations of SARS-CoV-2 infection and its vaccination"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Sep 11;97:102656. doi: 10.1016\/j.coi.2025.102656. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>SARS-CoV-2 infection and vaccination are associated with a broad range of skin manifestations, including chilblains, urticaria, morbilliform and papulovesicular rashes, purpuric-necrotic lesions, and autoimmune flares. These patterns reflect differences in the timing and nature of type I interferon (IFN-I) responses. Rapid TLR7-mediated IFN-I production by plasmacytoid dendritic cells (pDCs) in the upper airways restricts viral replication; hyperresponsive pDCs protect from severe infection but may cause chilblain-like lesions through exaggerated local inflammation. When early IFN-I responses are weak, viral spread to the lungs triggers endothelial cell death, mitochondrial DNA release, and cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation, producing a late IFN-I surge that amplifies inflammation, mirrored by morbilliform, vesicular, or necrotic skin lesions. mRNA and viral vector vaccines can similarly activate nucleic acid sensors, inducing IFN-I-driven rashes, and promote spike-specific T cells that cross-react with skin antigens. Recognizing these cutaneous signs offers insight into the balance between protective and pathogenic immunity in COVID-19.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40939529\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20250913004702&amp;v=2.18.0.post9+e462414\">40939529<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102656\">10.1016\/j.coi.2025.102656<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Sep 11;97:102656. doi: 10.1016\/j.coi.2025.102656. Online ahead of print. ABSTRACT SARS-CoV-2 infection and vaccination are associated with a broad range of skin manifestations, including chilblains, urticaria, morbilliform and papulovesicular rashes, purpuric-necrotic lesions, and autoimmune flares. These patterns reflect differences in the timing and nature of type I interferon (IFN-I) responses. Rapid TLR7-mediated &#8230; <a title=\"Skin manifestations of SARS-CoV-2 infection and its vaccination\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/13\/skin-manifestations-of-sars-cov-2-infection-and-its-vaccination\/\" aria-label=\"Read more about Skin manifestations of SARS-CoV-2 infection and its vaccination\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-43346","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43346","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=43346"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43346\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=43346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=43346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=43346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}