{"id":43360,"date":"2025-09-14T06:46:59","date_gmt":"2025-09-14T04:46:59","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/14\/smelling-lipid-cues-chemosensory-receptors-tune-tumor-associated-macrophage-behavior-martina-farber\/"},"modified":"2025-09-14T06:46:59","modified_gmt":"2025-09-14T04:46:59","slug":"smelling-lipid-cues-chemosensory-receptors-tune-tumor-associated-macrophage-behavior-martina-farber","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/14\/smelling-lipid-cues-chemosensory-receptors-tune-tumor-associated-macrophage-behavior-martina-farber\/","title":{"rendered":"&#8216;Smelling&#8217; lipid cues: chemosensory receptors tune tumor-associated macrophage behavior. Martina Farber"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Sep 12:S1471-4906(25)00218-2. doi: 10.1016\/j.it.2025.08.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Tumor-associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), but their heterogeneity, driven by tumor-derived cues, poses challenges for therapeutic targeting and underscores the need for precise macrophage reprogramming strategies. Through a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen, Marelli et al. identified chemosensors as lipid-sensing regulators of macrophage activity, revealing new therapeutic avenues.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40946000\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20250914004656&amp;v=2.18.0.post9+e462414\">40946000<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.08.008\">10.1016\/j.it.2025.08.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Sep 12:S1471-4906(25)00218-2. doi: 10.1016\/j.it.2025.08.008. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), but their heterogeneity, driven by tumor-derived cues, poses challenges for therapeutic targeting and underscores the need for precise macrophage reprogramming strategies. Through a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen, &#8230; <a title=\"&#8216;Smelling&#8217; lipid cues: chemosensory receptors tune tumor-associated macrophage behavior. Martina Farber\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/14\/smelling-lipid-cues-chemosensory-receptors-tune-tumor-associated-macrophage-behavior-martina-farber\/\" aria-label=\"Read more about &#8216;Smelling&#8217; lipid cues: chemosensory receptors tune tumor-associated macrophage behavior. Martina Farber\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-43360","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=43360"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43360\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=43360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=43360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=43360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}