{"id":43782,"date":"2025-09-21T06:48:42","date_gmt":"2025-09-21T04:48:42","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/21\/iga-dependent-cell-phagocytosis-of-hiv-infected-cells-elicits-cross-presentation-to-cd8t-cells-and-immune-memory-in-effector-monocytes-andrea-cottignies-calamarte\/"},"modified":"2025-09-21T06:48:42","modified_gmt":"2025-09-21T04:48:42","slug":"iga-dependent-cell-phagocytosis-of-hiv-infected-cells-elicits-cross-presentation-to-cd8t-cells-and-immune-memory-in-effector-monocytes-andrea-cottignies-calamarte","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/21\/iga-dependent-cell-phagocytosis-of-hiv-infected-cells-elicits-cross-presentation-to-cd8t-cells-and-immune-memory-in-effector-monocytes-andrea-cottignies-calamarte\/","title":{"rendered":"IgA-dependent cell phagocytosis of HIV-infected cells elicits cross-presentation to CD8+T cells and immune memory in effector monocytes. Andrea Cottignies-Calamarte"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Sep 18:S1933-0219(25)00094-7. doi: 10.1016\/j.mucimm.2025.09.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Mucosal IgA antibodies are the first defence against mucosal infections. Besides targeting specific antigens by their Fab-region, IgA also mediates antiviral functions via their Fc-domain, allowing infected cells destruction by antibody-dependent cellular phagocytosis (ADCP). Passive immunisation with anti-HIV-1 IgG protected Non-Human Primates in a CD8<sup>+<\/sup> T cell-dependent manner, a process likely involving ADCP. Here, we unravel the consequences of ADCP of HIV-1-infected cells mediated by anti-HIV envelope IgA compared to IgG. We found that IgA-mediated ADCP, not IgG, drives viral antigen cross-presentation to HIV-1-specific cytotoxic CD8<sup>+<\/sup> T cells. IgA effector function reprogrammed ADCP effector monocytes into activated macrophages exhibiting a mixed pro- and anti-inflammatory profile combined with increased pro-inflammatory chemokines. IgA-mediated ADCP sensitizes monocytes to respond to a novel bacterial challenge by secreting IL-6 and TNF\u03b1, indicative of acquired trained immunity. Altogether, these data establish a bridge between humoral and cellular immunity that could be exploited in HIV preventive strategies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40975322\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20250921004841&amp;v=2.18.0.post9+e462414\">40975322<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.09.004\">10.1016\/j.mucimm.2025.09.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Sep 18:S1933-0219(25)00094-7. doi: 10.1016\/j.mucimm.2025.09.004. Online ahead of print. ABSTRACT Mucosal IgA antibodies are the first defence against mucosal infections. Besides targeting specific antigens by their Fab-region, IgA also mediates antiviral functions via their Fc-domain, allowing infected cells destruction by antibody-dependent cellular phagocytosis (ADCP). Passive immunisation with anti-HIV-1 IgG protected Non-Human Primates in &#8230; <a title=\"IgA-dependent cell phagocytosis of HIV-infected cells elicits cross-presentation to CD8+T cells and immune memory in effector monocytes. Andrea Cottignies-Calamarte\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/21\/iga-dependent-cell-phagocytosis-of-hiv-infected-cells-elicits-cross-presentation-to-cd8t-cells-and-immune-memory-in-effector-monocytes-andrea-cottignies-calamarte\/\" aria-label=\"Read more about IgA-dependent cell phagocytosis of HIV-infected cells elicits cross-presentation to CD8+T cells and immune memory in effector monocytes. Andrea Cottignies-Calamarte\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-43782","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=43782"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/43782\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=43782"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=43782"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=43782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}