{"id":44217,"date":"2025-09-28T00:47:22","date_gmt":"2025-09-27T22:47:22","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/09\/28\/foreign-epitope-specific-regulatory-t-cells-respond-robustly-to-vaccination-and-limit-th1-differentiation-by-conventional-t-cells-specific-for-the-same-epitope\/"},"modified":"2025-09-28T00:47:22","modified_gmt":"2025-09-27T22:47:22","slug":"foreign-epitope-specific-regulatory-t-cells-respond-robustly-to-vaccination-and-limit-th1-differentiation-by-conventional-t-cells-specific-for-the-same-epitope","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/09\/28\/foreign-epitope-specific-regulatory-t-cells-respond-robustly-to-vaccination-and-limit-th1-differentiation-by-conventional-t-cells-specific-for-the-same-epitope\/","title":{"rendered":"Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Sep 27:vkaf254. doi: 10.1093\/jimmun\/vkaf254. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Foxp3+ regulatory T (Treg) cells with antigen receptors (TCRs) specific for host peptides suppress autoimmunity. Paradoxically, Treg cells are also found in CD4+ T-cell populations specific for foreign (nonhost) peptides. We investigated the origin and function of these Treg cells in mice. Populations of foreign peptide-specific na\u00efve CD4+ T cells contained Foxp3- conventional (Tconv) and Foxp3+ Treg cells in about a 90:10 ratio. Both types of T cells proliferated in parallel after vaccination with the foreign peptide in incomplete or complete Fruend&#8217;s adjuvants and formed memory cells. The Tconv population failed to express Foxp3, and formed Th1, Th17, and T follicular helper cells, whereas the Treg population largely retained Foxp3, and formed Th1- and Th17-like cells. The Treg cells specific for a foreign peptide had no effect on the proliferation of Tconv cells specific for that peptide but partially reduced Th1 cells in that population. Thus, foreign epitope-specific na\u00efve Treg cells fine-tune the primary response of Tconv cells specific for the same epitope by curbing the Th1 fate while allowing a robust response.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41014584\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20250927184722&amp;v=2.18.0.post9+e462414\">41014584<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf254\">10.1093\/jimmun\/vkaf254<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Sep 27:vkaf254. doi: 10.1093\/jimmun\/vkaf254. Online ahead of print. ABSTRACT Foxp3+ regulatory T (Treg) cells with antigen receptors (TCRs) specific for host peptides suppress autoimmunity. Paradoxically, Treg cells are also found in CD4+ T-cell populations specific for foreign (nonhost) peptides. We investigated the origin and function of these Treg cells in mice. Populations &#8230; <a title=\"Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/09\/28\/foreign-epitope-specific-regulatory-t-cells-respond-robustly-to-vaccination-and-limit-th1-differentiation-by-conventional-t-cells-specific-for-the-same-epitope\/\" aria-label=\"Read more about Foreign epitope-specific regulatory T cells respond robustly to vaccination and limit Th1 differentiation by conventional T cells specific for the same epitope\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-44217","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44217","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=44217"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44217\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=44217"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=44217"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=44217"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}