{"id":44620,"date":"2025-10-04T06:47:33","date_gmt":"2025-10-04T04:47:33","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/04\/potential-impact-of-long-read-sequencing-on-complement-mediated-diseases-sarah-m-carpanini\/"},"modified":"2025-10-04T06:47:33","modified_gmt":"2025-10-04T04:47:33","slug":"potential-impact-of-long-read-sequencing-on-complement-mediated-diseases-sarah-m-carpanini","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/04\/potential-impact-of-long-read-sequencing-on-complement-mediated-diseases-sarah-m-carpanini\/","title":{"rendered":"Potential impact of long-read sequencing on complement-mediated diseases. Sarah M Carpanini"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Oct 2:S1471-4906(25)00225-X. doi: 10.1016\/j.it.2025.09.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The complement genes harbour genetic variants that affect numerous diseases; however, these genes are notoriously repeat-heavy, and these repeat regions are largely unexplored for disease-relevant genetic variation. Elucidating these &#8216;dark&#8217; regions is now possible using long-read sequencing (LRS), enabling identification of novel disease-relevant genetic variants.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41044035\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251004004732&amp;v=2.18.0.post9+e462414\">41044035<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.09.006\">10.1016\/j.it.2025.09.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Oct 2:S1471-4906(25)00225-X. doi: 10.1016\/j.it.2025.09.006. Online ahead of print. ABSTRACT The complement genes harbour genetic variants that affect numerous diseases; however, these genes are notoriously repeat-heavy, and these repeat regions are largely unexplored for disease-relevant genetic variation. Elucidating these &#8216;dark&#8217; regions is now possible using long-read sequencing (LRS), enabling identification of novel disease-relevant &#8230; <a title=\"Potential impact of long-read sequencing on complement-mediated diseases. Sarah M Carpanini\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/04\/potential-impact-of-long-read-sequencing-on-complement-mediated-diseases-sarah-m-carpanini\/\" aria-label=\"Read more about Potential impact of long-read sequencing on complement-mediated diseases. Sarah M Carpanini\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-44620","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44620","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=44620"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44620\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=44620"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=44620"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=44620"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}