{"id":44861,"date":"2025-10-08T06:47:45","date_gmt":"2025-10-08T04:47:45","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/08\/unlocking-il-18-a-hidden-key-in-cancer-immunity-shima-sepehri-manesh\/"},"modified":"2025-10-08T06:47:45","modified_gmt":"2025-10-08T04:47:45","slug":"unlocking-il-18-a-hidden-key-in-cancer-immunity-shima-sepehri-manesh","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/08\/unlocking-il-18-a-hidden-key-in-cancer-immunity-shima-sepehri-manesh\/","title":{"rendered":"Unlocking IL-18: A hidden key in cancer immunity. Shima Sepehri-Manesh"},"content":{"rendered":"<div>\n<p><b>Semin Immunol<\/b>. 2025 Oct 6;80:101997. doi: 10.1016\/j.smim.2025.101997. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The IL-1 family comprises 11 cytokines, including IL-1\u03b1, IL-1\u03b2, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33, and IL-36 cytokines to IL-37 and IL-38, that modulate innate immune system activity. In addition to their role in innate immunity, IL-1 family members can activate and enhance the function of polarized T cells. For example, IL-33 primarily influences T helper 2 (T<sub>H<\/sub>2) cells, IL-1 plays a central role in the differentiation of T<sub>H<\/sub>17 cells, and IL-18 predominantly affects T<sub>H<\/sub>1 cells. The IL-1 family members participated in various biological functions as described elsewhere in this special issue. Here, we provide an overview on IL-18, originally called IFN-\u03b3 inducing factor, and its role in impacting cancer immunity.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41056758\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20251008004744&amp;v=2.18.0.post9+e462414\">41056758<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2025.101997\">10.1016\/j.smim.2025.101997<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2025 Oct 6;80:101997. doi: 10.1016\/j.smim.2025.101997. Online ahead of print. ABSTRACT The IL-1 family comprises 11 cytokines, including IL-1\u03b1, IL-1\u03b2, IL-1 receptor antagonist (IL-1Ra), IL-18, IL-33, and IL-36 cytokines to IL-37 and IL-38, that modulate innate immune system activity. In addition to their role in innate immunity, IL-1 family members can activate and enhance &#8230; <a title=\"Unlocking IL-18: A hidden key in cancer immunity. Shima Sepehri-Manesh\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/08\/unlocking-il-18-a-hidden-key-in-cancer-immunity-shima-sepehri-manesh\/\" aria-label=\"Read more about Unlocking IL-18: A hidden key in cancer immunity. Shima Sepehri-Manesh\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-44861","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=44861"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44861\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=44861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=44861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=44861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}