{"id":44934,"date":"2025-10-08T12:49:12","date_gmt":"2025-10-08T10:49:12","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/08\/a-mothers-touch-microbial-guardians-of-early-immune-imprinting-melody-y-zeng\/"},"modified":"2025-10-08T12:49:12","modified_gmt":"2025-10-08T10:49:12","slug":"a-mothers-touch-microbial-guardians-of-early-immune-imprinting-melody-y-zeng","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/08\/a-mothers-touch-microbial-guardians-of-early-immune-imprinting-melody-y-zeng\/","title":{"rendered":"A mother&#8217;s touch: microbial guardians of early immune imprinting. Melody Y Zeng"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Oct 6:S1471-4906(25)00227-3. doi: 10.1016\/j.it.2025.09.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The evolution of the fetal immune system within the womb is a delicate balancing act: it is trained to not reject maternal antigens, while equipping itself with &#8216;learned&#8217; immunity to survive and thrive in the outside world. In this opinion article, we propose that a deliberate maternal touch via immune and nutritional influences, orchestrated, in part, by microbiota-derived components, imprints the fetal immune system with the needed immune memory and epigenetic marks to navigate a far less nurturing outside world, including early microbial colonizers in the newborn&#8217;s intestine, pathogens and irritants, and allergens in food. We redefine the hygiene hypothesis to include prenatal maternal microbial exposures, priming fetal immune development for long-term fitness and reduced inflammatory\/autoimmune disease risk.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41058380\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251008064911&amp;v=2.18.0.post9+e462414\">41058380<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.09.008\">10.1016\/j.it.2025.09.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Oct 6:S1471-4906(25)00227-3. doi: 10.1016\/j.it.2025.09.008. Online ahead of print. ABSTRACT The evolution of the fetal immune system within the womb is a delicate balancing act: it is trained to not reject maternal antigens, while equipping itself with &#8216;learned&#8217; immunity to survive and thrive in the outside world. In this opinion article, we propose &#8230; <a title=\"A mother&#8217;s touch: microbial guardians of early immune imprinting. Melody Y Zeng\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/08\/a-mothers-touch-microbial-guardians-of-early-immune-imprinting-melody-y-zeng\/\" aria-label=\"Read more about A mother&#8217;s touch: microbial guardians of early immune imprinting. Melody Y Zeng\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-44934","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44934","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=44934"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/44934\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=44934"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=44934"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=44934"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}