{"id":45237,"date":"2025-10-13T00:48:28","date_gmt":"2025-10-12T22:48:28","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/13\/interferon-sensitized-hematopoietic-progenitors-dynamically-alter-organismal-immunity\/"},"modified":"2025-10-13T00:48:28","modified_gmt":"2025-10-12T22:48:28","slug":"interferon-sensitized-hematopoietic-progenitors-dynamically-alter-organismal-immunity","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/13\/interferon-sensitized-hematopoietic-progenitors-dynamically-alter-organismal-immunity\/","title":{"rendered":"Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Oct 12:vkaf249. doi: 10.1093\/jimmun\/vkaf249. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin inflammation and identified a surprising type I interferon (IFN)-mediated activation of hematopoietic stem\/progenitor cells (HSPCs) that results in profound changes to systemic host responses. Post-inflamed mice were protected from atherosclerosis and had worse outcomes following influenza virus infection. This IFN-mediated HSPC modulation was dependent on IFNAR signaling and could be recapitulated with the administration of recombinant IFN-\u03b1. Importantly, the transfer of post-inflamed HSPCs was sufficient to transmit the immune suppression phenotype. IFN modulation of HSPCs was rooted both in long-term changes in chromatin accessibility and the emergence of an IFN-responsive functional state from multiple progenitor populations. Collectively, our data reveal the profound and enduring effect of transient inflammation and more specifically type I IFN signaling and set the stage for a more nuanced understanding of HSPC functional modulation by peripheral immune signals.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41076641\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20251012184827&amp;v=2.18.0.post9+e462414\">41076641<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf249\">10.1093\/jimmun\/vkaf249<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Oct 12:vkaf249. doi: 10.1093\/jimmun\/vkaf249. Online ahead of print. ABSTRACT Inflammation has enduring impacts on organismal immunity. However, the precise mechanisms by which tissue-restricted inflammation conditions systemic responses are poorly understood. Here, we leveraged a highly compartmentalized model of skin inflammation and identified a surprising type I interferon (IFN)-mediated activation of hematopoietic stem\/progenitor &#8230; <a title=\"Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/13\/interferon-sensitized-hematopoietic-progenitors-dynamically-alter-organismal-immunity\/\" aria-label=\"Read more about Interferon-sensitized hematopoietic progenitors dynamically alter organismal immunity\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-45237","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/45237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=45237"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/45237\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=45237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=45237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=45237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}