{"id":45833,"date":"2025-10-15T15:48:32","date_gmt":"2025-10-15T13:48:32","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/15\/treating-sarcoidosis-when-less-is-more\/"},"modified":"2025-10-15T15:48:32","modified_gmt":"2025-10-15T13:48:32","slug":"treating-sarcoidosis-when-less-is-more","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/15\/treating-sarcoidosis-when-less-is-more\/","title":{"rendered":"Treating sarcoidosis: when less is more"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2025 Oct 13;97:102679. doi: 10.1016\/j.coi.2025.102679. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Sarcoidosis is a heterogeneous condition, with some presentations associated with spontaneous remission and favourable outcome without treatment. Other presentations, including small fibre neuropathy, arthropathy and sarcoid-associated fatigue, can cause disabling symptoms that may not respond to disease-modifying therapies and must be managed with symptom-based treatments. Sarcoidosis can also present with organ- or life-threatening manifestations, which must be managed with disease-modifying therapies. Glucocorticoids have traditionally been used as first-line therapy, although a recent randomised controlled trial has suggested that methotrexate as sole therapy may be equally effective in pulmonary sarcoidosis, although with delayed efficacy. Growing evidence of glucocorticoid-related toxicities in sarcoid patients is prompting a paradigm shift in treatment towards a &#8216;less is more&#8217; approach. In this review article, we will outline the current treatment of sarcoidosis with a particular focus on the shift away from the use of prolonged high-dose steroids.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41086651\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20251015094831&amp;v=2.18.0.post9+e462414\">41086651<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2025.102679\">10.1016\/j.coi.2025.102679<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2025 Oct 13;97:102679. doi: 10.1016\/j.coi.2025.102679. Online ahead of print. ABSTRACT Sarcoidosis is a heterogeneous condition, with some presentations associated with spontaneous remission and favourable outcome without treatment. Other presentations, including small fibre neuropathy, arthropathy and sarcoid-associated fatigue, can cause disabling symptoms that may not respond to disease-modifying therapies and must be managed &#8230; <a title=\"Treating sarcoidosis: when less is more\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/15\/treating-sarcoidosis-when-less-is-more\/\" aria-label=\"Read more about Treating sarcoidosis: when less is more\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-45833","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/45833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=45833"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/45833\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=45833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=45833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=45833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}