{"id":46198,"date":"2025-10-18T06:44:48","date_gmt":"2025-10-18T04:44:48","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/18\/threes-company-the-cooperative-signals-behind-the-differentiation-of-th9-cells-j-alejandra-rodriguez\/"},"modified":"2025-10-18T06:44:48","modified_gmt":"2025-10-18T04:44:48","slug":"threes-company-the-cooperative-signals-behind-the-differentiation-of-th9-cells-j-alejandra-rodriguez","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/18\/threes-company-the-cooperative-signals-behind-the-differentiation-of-th9-cells-j-alejandra-rodriguez\/","title":{"rendered":"Three&#8217;s company: The cooperative signals behind the differentiation of Th9 cells. J Alejandra Rodriguez"},"content":{"rendered":"<div>\n<p><b>Semin Immunol<\/b>. 2025 Oct 16;80:101999. doi: 10.1016\/j.smim.2025.101999. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>T helper 9 (Th9) cells, characterized by their production of interleukin-9 (IL-9), play pivotal roles in protective immunity and inflammatory disease. Their differentiation depends on the integration of three signals: TCR engagement (Signal 1), co-stimulatory receptor activation (Signal 2), and cytokine-driven transcriptional programming (Signal 3). This review explores how these signals converge to shape Th9 identity, highlighting the unique requirement for strong TCR signaling, heightened sensitivity to NF-\u03baB signaling pathways, and the interplay of cytokine\/STAT proteins. Understanding these mechanisms offers insights into Th9 biology and therapeutic strategies for cancer, allergy, and autoimmune disease.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41106133\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20251018004447&amp;v=2.18.0.post9+e462414\">41106133<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2025.101999\">10.1016\/j.smim.2025.101999<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2025 Oct 16;80:101999. doi: 10.1016\/j.smim.2025.101999. Online ahead of print. ABSTRACT T helper 9 (Th9) cells, characterized by their production of interleukin-9 (IL-9), play pivotal roles in protective immunity and inflammatory disease. Their differentiation depends on the integration of three signals: TCR engagement (Signal 1), co-stimulatory receptor activation (Signal 2), and cytokine-driven transcriptional programming &#8230; <a title=\"Three&#8217;s company: The cooperative signals behind the differentiation of Th9 cells. J Alejandra Rodriguez\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/18\/threes-company-the-cooperative-signals-behind-the-differentiation-of-th9-cells-j-alejandra-rodriguez\/\" aria-label=\"Read more about Three&#8217;s company: The cooperative signals behind the differentiation of Th9 cells. J Alejandra Rodriguez\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-46198","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=46198"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46198\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=46198"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=46198"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=46198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}