{"id":46199,"date":"2025-10-18T06:45:03","date_gmt":"2025-10-18T04:45:03","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/18\/t-follicular-helper-cells-drive-functionally-distinct-lymphoid-and-lung-resident-germinal-centres-and-limit-allergic-airway-disease-faith-i-uwadiae\/"},"modified":"2025-10-18T06:45:03","modified_gmt":"2025-10-18T04:45:03","slug":"t-follicular-helper-cells-drive-functionally-distinct-lymphoid-and-lung-resident-germinal-centres-and-limit-allergic-airway-disease-faith-i-uwadiae","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/18\/t-follicular-helper-cells-drive-functionally-distinct-lymphoid-and-lung-resident-germinal-centres-and-limit-allergic-airway-disease-faith-i-uwadiae\/","title":{"rendered":"T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease. Faith I Uwadiae"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Oct 15:S1933-0219(25)00107-2. doi: 10.1016\/j.mucimm.2025.10.005. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>T follicular helper cells (T<sub>FH<\/sub>) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, the precise role T<sub>FH<\/sub> play in AADs has remained elusive. Using a mouse model of chronic allergen induced AAD we now show that germinal centres (GCs) containing T<sub>FH<\/sub> and GC B cells accumulate in both the lung draining lymph nodes (dLNs) and the lungs themselves after allergen exposure. The formation of these GCs is dependent on T<sub>FH<\/sub>, as is generation of allergen specific IgA, IgG and IgE, with IgG1 and IgE-switched B cells being predominantly found in the dLNs while IgA switched B cells were only found in the lungs. Fitting with this, allergen-induced lung resident T<sub>FH<\/sub> and B cells are functionally and transcriptionally distinct from their lymphoid counterparts, with lung GCs providing a unique site of IgA-switch, a process that is partially IL-17A dependent. Finally while T<sub>FH<\/sub> deficiency did not worsen allergic airways disease after 3 weeks of aero-allergen exposure, worsened lung function and enhanced T<sub>H2<\/sub>-based inflammation in the respiratory tract were seen following 5 weeks of exposure. Overall these data suggest that T<sub>FH<\/sub> play a pivotal role in shaping immune responses both in the dLNs and the respiratory tract, and while they can promote key type-2 inflammatory pathways such as IgE production, they can also act to limit prolonged type-2 inflammation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41106482\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20251018004502&amp;v=2.18.0.post9+e462414\">41106482<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.10.005\">10.1016\/j.mucimm.2025.10.005<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Oct 15:S1933-0219(25)00107-2. doi: 10.1016\/j.mucimm.2025.10.005. Online ahead of print. ABSTRACT T follicular helper cells (TFH) play a central role in orchestrating antibody mediated immunity. Despite the importance of antibody responses, especially allergen-specific IgE, in allergic airway diseases (AAD) such as asthma, the precise role TFH play in AADs has remained elusive. Using a &#8230; <a title=\"T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease. Faith I Uwadiae\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/18\/t-follicular-helper-cells-drive-functionally-distinct-lymphoid-and-lung-resident-germinal-centres-and-limit-allergic-airway-disease-faith-i-uwadiae\/\" aria-label=\"Read more about T follicular helper cells drive functionally distinct lymphoid and lung resident germinal centres and limit allergic airway disease. Faith I Uwadiae\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-46199","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=46199"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46199\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=46199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=46199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=46199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}