{"id":46741,"date":"2025-10-26T02:47:29","date_gmt":"2025-10-26T01:47:29","guid":{"rendered":"https:\/\/inmuno.es\/?p=46741"},"modified":"2025-10-26T02:47:29","modified_gmt":"2025-10-26T01:47:29","slug":"postnatal-liver-b-cell-precursors-contribute-to-the-establishment-of-a-mature-b-cell-pool-in-secondary-lymphoid-organs-in-mice","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/26\/postnatal-liver-b-cell-precursors-contribute-to-the-establishment-of-a-mature-b-cell-pool-in-secondary-lymphoid-organs-in-mice\/","title":{"rendered":"Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Oct 25:vkaf264. doi: 10.1093\/jimmun\/vkaf264. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The liver contains a diverse repertoire of leukocytes, with liver B cells representing a significant population of hepatic immune cells in both newborns and adults. Despite their importance, these cells remain largely unexplored. In this study, we comprehensively characterized liver B cells from newborns through adulthood in both humans and mice applying a combination of in vivo imaging, immunophenotyping, RNA sequencing, and cell transfer protocols to characterize hepatic B cell subtypes from birth to adulthood. We found that newborn liver B cell population are transcriptionally and phenotypically distinct from those in adults, with significant alterations in genes related to immunoglobulin processing, release, and major histocompatibility complex class I and II functions. Photoconversion-based tracking revealed that liver-resident B cells actively migrate to distant lymphoid organs, including the spleen and bone marrow, where they integrate into the mature immune cell pool. Our findings establish the newborn liver as a crucial niche for B cell maturation and migration, highlighting its role in seeding secondary lymphoid organs and contributing to immune function throughout life. These insights provide new understanding of liver-derived B cells in the postnatal development of the immune system.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41138221\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20251025204728&amp;v=2.18.0.post22+67771e2\">41138221<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf264\">10.1093\/jimmun\/vkaf264<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Oct 25:vkaf264. doi: 10.1093\/jimmun\/vkaf264. Online ahead of print. ABSTRACT The liver contains a diverse repertoire of leukocytes, with liver B cells representing a significant population of hepatic immune cells in both newborns and adults. Despite their importance, these cells remain largely unexplored. In this study, we comprehensively characterized liver B cells from &#8230; <a title=\"Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/26\/postnatal-liver-b-cell-precursors-contribute-to-the-establishment-of-a-mature-b-cell-pool-in-secondary-lymphoid-organs-in-mice\/\" aria-label=\"Read more about Postnatal liver B cell precursors contribute to the establishment of a mature B cell pool in secondary lymphoid organs in mice\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-46741","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=46741"}],"version-history":[{"count":1,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46741\/revisions"}],"predecessor-version":[{"id":46742,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46741\/revisions\/46742"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=46741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=46741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=46741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}