{"id":46849,"date":"2025-10-27T18:47:19","date_gmt":"2025-10-27T17:47:19","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/27\/the-janus-face-of-nk-cells-in-neurodevelopment-qiwu-bian\/"},"modified":"2025-10-27T18:47:19","modified_gmt":"2025-10-27T17:47:19","slug":"the-janus-face-of-nk-cells-in-neurodevelopment-qiwu-bian","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/27\/the-janus-face-of-nk-cells-in-neurodevelopment-qiwu-bian\/","title":{"rendered":"The Janus face of NK cells in neurodevelopment. Qiwu Bian"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Oct 25:S1471-4906(25)00245-5. doi: 10.1016\/j.it.2025.10.001. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Maternal immune activation (MIA), triggered by infection or inflammation during pregnancy, is a well-recognized risk factor for neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD). Clinical cohort studies and rodent models suggest that natural killer (NK) cells play a significant role in NDD pathogenesis, but the underlying mechanisms remain poorly defined. Here, we summarize the key immune mediators involved in MIA-induced NDDs, emphasizing microglia as a central hub. We then examine emerging evidence implicating aberrant NK cell activation in ASD, underscoring their overlooked contribution to impaired neurodevelopment. Finally, we discuss potential mechanisms of NK cell-microglia crosstalk in NDDs. Elucidating these interactions in the context of MIA will be crucial for developing preventive and therapeutic strategies against inflammation-driven NDDs.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41139560\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251027134718&amp;v=2.18.0.post22+67771e2\">41139560<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.10.001\">10.1016\/j.it.2025.10.001<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Oct 25:S1471-4906(25)00245-5. doi: 10.1016\/j.it.2025.10.001. Online ahead of print. ABSTRACT Maternal immune activation (MIA), triggered by infection or inflammation during pregnancy, is a well-recognized risk factor for neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD). Clinical cohort studies and rodent models suggest that natural killer (NK) cells play a significant role in &#8230; <a title=\"The Janus face of NK cells in neurodevelopment. Qiwu Bian\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/27\/the-janus-face-of-nk-cells-in-neurodevelopment-qiwu-bian\/\" aria-label=\"Read more about The Janus face of NK cells in neurodevelopment. Qiwu Bian\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-46849","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=46849"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/46849\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=46849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=46849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=46849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}