{"id":47255,"date":"2025-10-31T11:48:58","date_gmt":"2025-10-31T10:48:58","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/31\/immunological-aspects-of-naturally-occurring-model-of-hepatitis-b-virus-hbv-infection-hepatitis-b-and-hbv-associated-hepatocellular-carcinoma-in-the-american-woodchuck-marmota-monax\/"},"modified":"2025-10-31T11:48:58","modified_gmt":"2025-10-31T10:48:58","slug":"immunological-aspects-of-naturally-occurring-model-of-hepatitis-b-virus-hbv-infection-hepatitis-b-and-hbv-associated-hepatocellular-carcinoma-in-the-american-woodchuck-marmota-monax","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/31\/immunological-aspects-of-naturally-occurring-model-of-hepatitis-b-virus-hbv-infection-hepatitis-b-and-hbv-associated-hepatocellular-carcinoma-in-the-american-woodchuck-marmota-monax\/","title":{"rendered":"Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Oct 1;214(10):2504-2514. doi: 10.1093\/jimmun\/vkaf231.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic model of hepatitis type B that, like in humans, can advance stepwise from acute hepatitis to chronic hepatitis and hepatocellular carcinoma (HCC) or become self-resolving and persist as a clinically asymptomatic infection throughout the lifespan. This naturally occurring model is utilized for both basic research and preclinical assessments of anti-hepatitis B virus (HBV) agents and immunotherapies against chronic hepatitis B and HCC. The main advantages of the system include a close molecular and immunogenic compatibility between HBV and WHV, equivalence in immune responses in different forms of infection and stages of hepatitis, human-compatible responsiveness to antivirals and immunotherapies, and the fact that virus-host interactions occur in an innately virus-susceptible, immunologically intact host. Woodchuck-WHV infection offers a well-characterized and all-inclusive system to advance studies on HBV pathogenicity and oncogenicity, and for discovery and preclinical validations of new therapies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41169234\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20251031064857&amp;v=2.18.0.post22+67771e2\">41169234<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf231\">10.1093\/jimmun\/vkaf231<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Oct 1;214(10):2504-2514. doi: 10.1093\/jimmun\/vkaf231. ABSTRACT Infection of eastern North American woodchucks (Marmota monax) with woodchuck hepatitis virus (WHV) represents the most valuable immunopathogenic model of hepatitis type B that, like in humans, can advance stepwise from acute hepatitis to chronic hepatitis and hepatocellular carcinoma (HCC) or become self-resolving and persist as a &#8230; <a title=\"Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/31\/immunological-aspects-of-naturally-occurring-model-of-hepatitis-b-virus-hbv-infection-hepatitis-b-and-hbv-associated-hepatocellular-carcinoma-in-the-american-woodchuck-marmota-monax\/\" aria-label=\"Read more about Immunological aspects of naturally occurring model of hepatitis B virus (HBV) infection, hepatitis B, and HBV-associated hepatocellular carcinoma in the American woodchuck Marmota monax\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-47255","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=47255"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47255\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=47255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=47255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=47255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}