{"id":47280,"date":"2025-10-31T23:49:39","date_gmt":"2025-10-31T22:49:39","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/10\/31\/ccr2-driven-monocyte-recruitment-is-protective-against-radiotherapy-induced-intestinal-toxicity-nabina-pun\/"},"modified":"2025-10-31T23:49:39","modified_gmt":"2025-10-31T22:49:39","slug":"ccr2-driven-monocyte-recruitment-is-protective-against-radiotherapy-induced-intestinal-toxicity-nabina-pun","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/10\/31\/ccr2-driven-monocyte-recruitment-is-protective-against-radiotherapy-induced-intestinal-toxicity-nabina-pun\/","title":{"rendered":"CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity. Nabina Pun"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Oct 24:S1933-0219(25)00113-8. doi: 10.1016\/j.mucimm.2025.10.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is known to help regulate tissue damage, immune mechanisms involved in RT-induced intestinal toxicity are not fully understood. Following CT-guided localised intestinal irradiation, single-cell RNA sequencing (scRNA-seq) and flow cytometry revealed RT-induced chemokine-dependent recruitment of innate immune cells. Deletion of C-C chemokine receptor (Ccr)1, Ccr2, Ccr3 and Ccr5, blocked recruitment and worsened radiation-induced toxicities, suggesting an important role for an innate immune cell population in limiting RT-mediated bowel damage. Furthermore, CCR2-deficient mice showed exacerbated weight loss and intestinal permeability, while the transfer of Ly6C<sup>+<\/sup> monocytes alleviated symptoms. Mechanistically, IL-17 cytokine production by group 3 innate lymphoid cells (ILC3s), a critical factor in maintaining intestinal barrier integrity, was found to be reduced in irradiated CCR2<sup>-\/-<\/sup>, moreover the transfer of Ly6C<sup>+<\/sup> monocytes resulted in increased IL-17 levels. These findings demonstrate the critical importance of CCR2-mediated monocyte recruitment in mitigating RT-induced toxicities. One Sentence Summary: CCR2-mediated monocyte recruitment protects against RT-induced intestinal toxicity via IL-17, highlighting a therapeutic target.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41171691\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20251031184938&amp;v=2.18.0.post22+67771e2\">41171691<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.10.008\">10.1016\/j.mucimm.2025.10.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Oct 24:S1933-0219(25)00113-8. doi: 10.1016\/j.mucimm.2025.10.008. Online ahead of print. ABSTRACT Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is known to help regulate tissue damage, immune mechanisms involved in RT-induced &#8230; <a title=\"CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity. Nabina Pun\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/10\/31\/ccr2-driven-monocyte-recruitment-is-protective-against-radiotherapy-induced-intestinal-toxicity-nabina-pun\/\" aria-label=\"Read more about CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity. Nabina Pun\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-47280","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=47280"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47280\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=47280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=47280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=47280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}