{"id":47767,"date":"2025-11-08T06:53:34","date_gmt":"2025-11-08T05:53:34","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/08\/dna-methylation-and-histone-modifications-drive-the-trained-immunity-duration-mohua-liu\/"},"modified":"2025-11-08T06:53:34","modified_gmt":"2025-11-08T05:53:34","slug":"dna-methylation-and-histone-modifications-drive-the-trained-immunity-duration-mohua-liu","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/08\/dna-methylation-and-histone-modifications-drive-the-trained-immunity-duration-mohua-liu\/","title":{"rendered":"DNA methylation and histone modifications drive the trained immunity duration. Mohua Liu"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Nov 6:S1471-4906(25)00248-0. doi: 10.1016\/j.it.2025.10.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Trained immunity (TRIM) is a de facto form of innate immune memory. While histone modifications contribute to TRIM, their reversible nature and susceptibility to dilution during cell division cannot fully account for its long-term persistence. Here, we propose that DNA methylation patterns, particularly hypomethylation at proinflammatory gene loci, could serve as a key epigenetic mechanism contributing to long-term TRIM. Mechanistically, these hypomethylated states are biochemically stable and faithfully inherited through cell division, acting as a permissive scaffold that enables the rapid accumulation of activating histone marks upon restimulation. This DNA-methylation-mediated process could underpin the durability of TRIM across multiple contexts, including hematopoietic stem cell self-renewal, differentiation from central to peripheral compartments, and autonomy of tissue-resident cells.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41203534\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251108005334&amp;v=2.18.0.post22+67771e2\">41203534<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.10.004\">10.1016\/j.it.2025.10.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Nov 6:S1471-4906(25)00248-0. doi: 10.1016\/j.it.2025.10.004. Online ahead of print. ABSTRACT Trained immunity (TRIM) is a de facto form of innate immune memory. While histone modifications contribute to TRIM, their reversible nature and susceptibility to dilution during cell division cannot fully account for its long-term persistence. Here, we propose that DNA methylation patterns, particularly &#8230; <a title=\"DNA methylation and histone modifications drive the trained immunity duration. Mohua Liu\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/08\/dna-methylation-and-histone-modifications-drive-the-trained-immunity-duration-mohua-liu\/\" aria-label=\"Read more about DNA methylation and histone modifications drive the trained immunity duration. Mohua Liu\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-47767","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=47767"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47767\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=47767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=47767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=47767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}