{"id":47778,"date":"2025-11-09T06:46:59","date_gmt":"2025-11-09T05:46:59","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/09\/epigenetically-programmed-identity-crisis-to-combat-diffuse-large-b-cell-lymphoma-rachele-niccolai\/"},"modified":"2025-11-09T06:46:59","modified_gmt":"2025-11-09T05:46:59","slug":"epigenetically-programmed-identity-crisis-to-combat-diffuse-large-b-cell-lymphoma-rachele-niccolai","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/09\/epigenetically-programmed-identity-crisis-to-combat-diffuse-large-b-cell-lymphoma-rachele-niccolai\/","title":{"rendered":"Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma. Rachele Niccolai"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Nov 7:S1471-4906(25)00251-0. doi: 10.1016\/j.it.2025.10.007. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Germinal center B cell-like diffuse large B cell lymphoma (GCB-DLBCL) originates from the malignant transformation of germinal center B cells. This process is driven by transcriptional and epigenetic dysregulations, frequently caused by recurrent mutations and chromosomal translocations. These changes lead to a differentiation arrest associated with unchecked proliferation and survival. This review highlights key transcriptional and epigenetic dependencies that sustain the GCB-DLBCL phenotype and identifies therapeutic vulnerabilities. Epigenetic targeting of these vulnerabilities unlocks tumor cells from their differentiation arrest, enabling further yet incomplete differentiation toward an antiproliferative, proapoptotic plasma cell-like or memory B cell-like state. We define this transition as an epigenetically programmed identity crisis, a promising therapeutic strategy to target GCB-DLBCL and potentially other malignancies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41206331\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251109004659&amp;v=2.18.0.post22+67771e2\">41206331<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.10.007\">10.1016\/j.it.2025.10.007<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Nov 7:S1471-4906(25)00251-0. doi: 10.1016\/j.it.2025.10.007. Online ahead of print. ABSTRACT Germinal center B cell-like diffuse large B cell lymphoma (GCB-DLBCL) originates from the malignant transformation of germinal center B cells. This process is driven by transcriptional and epigenetic dysregulations, frequently caused by recurrent mutations and chromosomal translocations. These changes lead to a differentiation &#8230; <a title=\"Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma. Rachele Niccolai\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/09\/epigenetically-programmed-identity-crisis-to-combat-diffuse-large-b-cell-lymphoma-rachele-niccolai\/\" aria-label=\"Read more about Epigenetically programmed identity crisis to combat diffuse large B cell lymphoma. Rachele Niccolai\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-47778","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=47778"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47778\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=47778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=47778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=47778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}