{"id":47829,"date":"2025-11-09T12:00:00","date_gmt":"2025-11-09T11:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/09\/impact-of-immune-cells-on-iga-vasculitis-via-metabolites-and-inflammatory-cytokines\/"},"modified":"2025-11-09T12:00:00","modified_gmt":"2025-11-09T11:00:00","slug":"impact-of-immune-cells-on-iga-vasculitis-via-metabolites-and-inflammatory-cytokines","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/09\/impact-of-immune-cells-on-iga-vasculitis-via-metabolites-and-inflammatory-cytokines\/","title":{"rendered":"Impact of Immune Cells on IgA Vasculitis via Metabolites and Inflammatory Cytokines"},"content":{"rendered":"
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J Clin Immunol<\/b>. 2025 Nov 10;45(1):157. doi: 10.1007\/s10875-025-01946-3.<\/p>\n

ABSTRACT<\/b><\/p>\n

BACKGROUND: IgA vasculitis (IgAV) is an autoimmune disorder characterized by inflammation of the small blood vessels. The pathogenesis of IgAV is believed to involve a complex interplay between immune cells, metabolites, and inflammatory cytokines (ICs).<\/p>\n

METHODS: We performed two-sample Mendelian randomization (MR) analysis to examine the causal relationship between immune cell traits, metabolites, ICs, and IgAV. Genetic variants associated with exposure, mediators and outcome were extracted from large-scale genome-wide association studies (GWAS). The inverse variance weighted (IVW) method was used as the primary approach, supported by MR Egger, weighted median, simple mode, and weighted mode methods.<\/p>\n

RESULTS: In this study, we identified 25 immune cells, 6 metabolites (Threonate, Carnitine C5:1, Chiro-inositol, Carnitine C18:2, 3-formylindole, Cholate to phosphate ratio) and 2 ICs (T – cell surface glycoprotein CD5, Osteoprotegerin) associated with IgAV. Meanwhile, we identified 5 immune cell-metabolites-IgAV pathways (CD28+<\/sup>CD45RA–<\/sup>CD8dim AC-3-formylindole-IgAV; CD28+<\/sup> CD45RA–<\/sup> CD8dim AC-Cholate to phosphate ratio-IgAV; CD28+<\/sup> CD45RA+<\/sup> CD8br%T cell-3-formylindole-IgAV; CD25 on IgD+<\/sup> CD38–<\/sup> unswmem-Chiro-inositol- IgAV; HLA DR on CD14+<\/sup> CD16–<\/sup> monocyte-Chiro-inositol-IgAV; CD39+<\/sup> secreting Treg %secreting Treg-Threonate-IgAV) and 4 immune cells-ICs-IgAV pathways (IgD–<\/sup> CD38–<\/sup> AC-Osteoprotegerin-IgAV; CD45 on T-Osteoprotegerin-IgAV; HLA DR on CD14+<\/sup> CD16–<\/sup> monocyte-CD5-IgAV; HLA DR on CD14+<\/sup>CD16–<\/sup> monocyte-CD5-IgAV).<\/p>\n

CONCLUSIONS: These results highlight the need for further research to investigate the underlying mechanisms and identify potential therapeutic targets for the treatment of IgAV.<\/p>\n

PMID:41207983<\/a> | DOI:10.1007\/s10875-025-01946-3<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Clin Immunol. 2025 Nov 10;45(1):157. doi: 10.1007\/s10875-025-01946-3. ABSTRACT BACKGROUND: IgA vasculitis (IgAV) is an autoimmune disorder characterized by inflammation of the small blood vessels. The pathogenesis of IgAV is believed to involve a complex interplay between immune cells, metabolites, and inflammatory cytokines (ICs). METHODS: We performed two-sample Mendelian randomization (MR) analysis to examine the … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-47829","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=47829"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47829\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=47829"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=47829"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=47829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}