{"id":47840,"date":"2025-11-10T17:49:35","date_gmt":"2025-11-10T16:49:35","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/10\/not-just-passing-through-bone-marrow-as-a-home-for-diverse-resident-t-cells-valuekyra-d-zens-klaas-p-j-m-van-gisbergen\/"},"modified":"2025-11-10T17:49:35","modified_gmt":"2025-11-10T16:49:35","slug":"not-just-passing-through-bone-marrow-as-a-home-for-diverse-resident-t-cells-valuekyra-d-zens-klaas-p-j-m-van-gisbergen","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/10\/not-just-passing-through-bone-marrow-as-a-home-for-diverse-resident-t-cells-valuekyra-d-zens-klaas-p-j-m-van-gisbergen\/","title":{"rendered":"Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells. [[{&#8220;value&#8221;:&#8221;Kyra D. Zens, \nKlaas P. J. M. van Gisbergen&#8221;}]]"},"content":{"rendered":"<p><img decoding=\"async\" src=\"https:\/\/onlinelibrary.wiley.com\/cms\/asset\/5928c105-d355-44cc-bcf4-328c0d3ae2c8\/eji70083-gra-0001-m.png\" alt=\"Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells\" \/><\/p>\n<p>CD8<sup>+<\/sup>CD69<sup>\u2212<\/sup> memory T cells (Schneider Revueltas et\u00a0al.) were identified to reside in bone marrow besides canonical CD8<sup>+<\/sup>CD69<sup>+<\/sup> tissue-resident memory T cells (TRM). In addition, CD4<sup>+<\/sup>CD69<sup>+<\/sup> Tr1-like cells (Pulvirenti et\u00a0al.) were preferentially found in bone marrow. Together, these findings illustrate diversity in the T cell subsets that reside long-term within the bone marrow.<\/p>\n<p><\/p>\n<h2>ABSTRACT<\/h2>\n<p>Recent studies add to our understanding of T cell residency in the human bone marrow (BM). In the May 2025 issue of EJI, Schneider Revueltas et\u00a0al. demonstrate that CD69<sup>\u2212<\/sup> CD4<sup>+<\/sup> and CD8+ memory T cells, presumed to be recirculating, have a distinct transcriptional cluster profile and a distinct TCR repertoire from their blood counterparts. These findings are in line with CD69<sup>\u2212<\/sup> memory T cells taking up residence in the BM, similar to their CD69<sup>+<\/sup> counterparts. In parallel, Pulvirenti et\u00a0al. identify a subset of CD69<sup>+<\/sup>EOMES<sup>+<\/sup>GzmK<sup>+<\/sup> Tr1-like cells in the BM maintained by IL-15. Together, these studies refine our understanding of the BM as a heterogeneous immune niche and suggest a broader definition of resident cells within this tissue.<\/p>","protected":false},"excerpt":{"rendered":"<p>CD8+CD69\u2212 memory T cells (Schneider Revueltas et\u00a0al.) were identified to reside in bone marrow besides canonical CD8+CD69+ tissue-resident memory T cells (TRM). In addition, CD4+CD69+ Tr1-like cells (Pulvirenti et\u00a0al.) were preferentially found in bone marrow. Together, these findings illustrate diversity in the T cell subsets that reside long-term within the bone marrow. ABSTRACT Recent studies &#8230; <a title=\"Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells. [[{&#8220;value&#8221;:&#8221;Kyra D. Zens, \nKlaas P. J. M. van Gisbergen&#8221;}]]\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/10\/not-just-passing-through-bone-marrow-as-a-home-for-diverse-resident-t-cells-valuekyra-d-zens-klaas-p-j-m-van-gisbergen\/\" aria-label=\"Read more about Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells. [[{&#8220;value&#8221;:&#8221;Kyra D. Zens, \nKlaas P. J. M. van Gisbergen&#8221;}]]\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,42],"tags":[],"class_list":["post-47840","post","type-post","status-publish","format-standard","hentry","category-european-journal-of-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=47840"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/47840\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=47840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=47840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=47840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}