{"id":48676,"date":"2025-11-13T18:44:06","date_gmt":"2025-11-13T17:44:06","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/13\/pan-cancer-single-cell-rna-sequencing-analysis-refines-multi-origin-monocyte-and-macrophage-lineages\/"},"modified":"2025-11-13T18:44:06","modified_gmt":"2025-11-13T17:44:06","slug":"pan-cancer-single-cell-rna-sequencing-analysis-refines-multi-origin-monocyte-and-macrophage-lineages","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/13\/pan-cancer-single-cell-rna-sequencing-analysis-refines-multi-origin-monocyte-and-macrophage-lineages\/","title":{"rendered":"Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages"},"content":{"rendered":"<div>\n<p><b>Cancer Immunol Res<\/b>. 2025 Nov 13. doi: 10.1158\/2326-6066.CIR-24-1255. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Tumor-associated macrophages (TAMs) play crucial and important role in cancer dynamics by affecting homeostasis, immunosuppression, and angiogenesis within the tumor microenvironment. Using single-cell transcriptomics, we constructed a comprehensive atlas of myeloid cell populations across healthy and pan-cancer tissues that revealed heterogeneity. Our analysis suggested that TAMs may arise from two distinct origins: C1QC+ TAMs, which likely are derived from resident tissue macrophages, SPP1+ TAMs and ISG15+ TAMs, which appear to originate from circulating monocytes. Regarding immature myeloid-derived suppressor cells (MDSCs), we highlighted THBS1+ MDSCs and their descendants, SPP1+ TAMs, as key contributors to tumor progression, immunosuppression, and angiogenesis. We proposed a dichotomous model for TAMs, in which C1QC+ TAMs are associated with better patient outcomes, whereas the THBS1+ MDSCs &#8211; SPP1+ TAMs lineage correlates with poorer survival and unfavorable response to immunotherapy. This study offers insight into the complex interactions among monocyte-macrophage subtypes and sheds light on TAM heterogeneity and its implications for cancer progression and therapeutic strategies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41231218\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101614637&amp;ff=20251113124405&amp;v=2.18.0.post22+67771e2\">41231218<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1158\/2326-6066.CIR-24-1255\">10.1158\/2326-6066.CIR-24-1255<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Cancer Immunol Res. 2025 Nov 13. doi: 10.1158\/2326-6066.CIR-24-1255. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) play crucial and important role in cancer dynamics by affecting homeostasis, immunosuppression, and angiogenesis within the tumor microenvironment. Using single-cell transcriptomics, we constructed a comprehensive atlas of myeloid cell populations across healthy and pan-cancer tissues that revealed heterogeneity. Our &#8230; <a title=\"Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/13\/pan-cancer-single-cell-rna-sequencing-analysis-refines-multi-origin-monocyte-and-macrophage-lineages\/\" aria-label=\"Read more about Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55,42],"tags":[],"class_list":["post-48676","post","type-post","status-publish","format-standard","hentry","category-cancer-immunology-reserch","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/48676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=48676"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/48676\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=48676"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=48676"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=48676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}