{"id":48728,"date":"2025-11-14T12:26:16","date_gmt":"2025-11-14T11:26:16","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/14\/building-tolerance-employing-genome-engineering-toward-universal-treg-therapyjulian-j-freen-van-heeren-on-14-de-november-de-2025-at-1100\/"},"modified":"2025-11-14T12:26:16","modified_gmt":"2025-11-14T11:26:16","slug":"building-tolerance-employing-genome-engineering-toward-universal-treg-therapyjulian-j-freen-van-heeren-on-14-de-november-de-2025-at-1100","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/14\/building-tolerance-employing-genome-engineering-toward-universal-treg-therapyjulian-j-freen-van-heeren-on-14-de-november-de-2025-at-1100\/","title":{"rendered":"Building Tolerance: Employing Genome Engineering Toward Universal Treg Therapy\u200bJulian J Freen-van Heeren   on 14 de November de 2025 at 11:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2025 Nov 14:qiaf164. doi: 10.1093\/jleuko\/qiaf164. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR deletion of B2M and CIITA and insertion of an HLA-E-B2M fusion, the authors produced hypo-immunogenic Tregs that persisted and promoted graft tolerance in humanized mice. In this News and Views, the promise and challenges of such universal &#8220;off-the-shelf&#8221; Tregs are discussed, emphasizing how genome engineering is reshaping Treg biology into a new era of programmable immune tolerance.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41234126\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20251114062615&amp;v=2.18.0.post22+67771e2\">41234126<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf164\">10.1093\/jleuko\/qiaf164<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2025 Nov 14:qiaf164. doi: 10.1093\/jleuko\/qiaf164. Online ahead of print. ABSTRACT Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR &#8230; <a title=\"Building Tolerance: Employing Genome Engineering Toward Universal Treg Therapy\u200bJulian J Freen-van Heeren   on 14 de November de 2025 at 11:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/14\/building-tolerance-employing-genome-engineering-toward-universal-treg-therapyjulian-j-freen-van-heeren-on-14-de-november-de-2025-at-1100\/\" aria-label=\"Read more about Building Tolerance: Employing Genome Engineering Toward Universal Treg Therapy\u200bJulian J Freen-van Heeren   on 14 de November de 2025 at 11:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-48728","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/48728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=48728"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/48728\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=48728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=48728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=48728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}