{"id":48942,"date":"2025-11-17T12:00:00","date_gmt":"2025-11-17T11:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/17\/the-spectrum-of-bacterial-infection-in-a-large-cohort-of-chinese-pediatric-patients-with-inborn-errors-of-immunity-a-nine-year-retrospective-single-center-study\/"},"modified":"2025-11-17T12:00:00","modified_gmt":"2025-11-17T11:00:00","slug":"the-spectrum-of-bacterial-infection-in-a-large-cohort-of-chinese-pediatric-patients-with-inborn-errors-of-immunity-a-nine-year-retrospective-single-center-study","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/17\/the-spectrum-of-bacterial-infection-in-a-large-cohort-of-chinese-pediatric-patients-with-inborn-errors-of-immunity-a-nine-year-retrospective-single-center-study\/","title":{"rendered":"The Spectrum of Bacterial Infection in a Large Cohort of Chinese Pediatric Patients with Inborn Errors of Immunity: A Nine-year, Retrospective, Single-center Study"},"content":{"rendered":"<div>\n<p><b>J Clin Immunol<\/b>. 2025 Nov 18;45(1):163. doi: 10.1007\/s10875-025-01964-1.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>PURPOSE: This study aimed to investigate the spectrum of bacterial infections in children with inborn error of immunity (IEIs).<\/p>\n<p>METHODS: Pediatric patients with IEIs and positive for bacteria considered to be pathogenic were included in this retrospective study.<\/p>\n<p>RESULTS: In this study, 1811 medical records of IEI inpatients were reviewed, and 243 IEI patients with 290 hospitalizations were enrolled. A total of 361 strains were detected, of which, 83 (22.99%) were gram-positive bacteria, and 278 (77.01%) were gram-negative bacteria. The main bacteria isolated from different IEI classifications were different. Patients with combined immunodeficiencies were more likely to have Klebsiella pneumoniae (12.68%) and Pseudomonas aeruginosa (12.68%) isolated. Patients with predominant antibody deficiencies were more prone to the isolation of Haemophilus influenzae (31.82%) and Moraxella catarrhalis (13.64%). Patients with congenital defects of phagocytes were more frequently associated with the isolation of K. pneumoniae (16.84%) and Escherichia coli (11.58%). Patients with different classifications of IEI were susceptible to specific bacteria. Salmonella was often isolated from patients with defects in intrinsic and innate immunity (4.23%), and Staphylococcus aureus was often isolated from patients with combined immunodeficiencies with syndromic features (5.52%). The percentages of methicillin-resistant S. aureus, carbapenem-resistant E. coli, K. pneumoniae, P. aeruginosa, and Acinetobacter baumannii in IEI patients were55.57%, 38.10%, 25.71%, 25.81%, and 70.59%, respectively, and these values were greater than those in non-IEI patients.<\/p>\n<p>CONCLUSION: Children with IEIs exhibit a unique spectrum of bacterial infections. Bacteria isolated from children with IEIs have high antimicrobial resistance.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41249685\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20251118002958&amp;v=2.18.0.post22+67771e2\">41249685<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-025-01964-1\">10.1007\/s10875-025-01964-1<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2025 Nov 18;45(1):163. doi: 10.1007\/s10875-025-01964-1. ABSTRACT PURPOSE: This study aimed to investigate the spectrum of bacterial infections in children with inborn error of immunity (IEIs). METHODS: Pediatric patients with IEIs and positive for bacteria considered to be pathogenic were included in this retrospective study. RESULTS: In this study, 1811 medical records of &#8230; <a title=\"The Spectrum of Bacterial Infection in a Large Cohort of Chinese Pediatric Patients with Inborn Errors of Immunity: A Nine-year, Retrospective, Single-center Study\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/17\/the-spectrum-of-bacterial-infection-in-a-large-cohort-of-chinese-pediatric-patients-with-inborn-errors-of-immunity-a-nine-year-retrospective-single-center-study\/\" aria-label=\"Read more about The Spectrum of Bacterial Infection in a Large Cohort of Chinese Pediatric Patients with Inborn Errors of Immunity: A Nine-year, Retrospective, Single-center Study\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-48942","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/48942","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=48942"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/48942\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=48942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=48942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=48942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}