{"id":49176,"date":"2025-11-20T06:51:10","date_gmt":"2025-11-20T05:51:10","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/20\/cervical-mucosal-inflammation-expands-functional-polymorphonuclear-myeloid-derived-suppressor-cells-daan-k-j-pieren\/"},"modified":"2025-11-20T06:51:10","modified_gmt":"2025-11-20T05:51:10","slug":"cervical-mucosal-inflammation-expands-functional-polymorphonuclear-myeloid-derived-suppressor-cells-daan-k-j-pieren","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/20\/cervical-mucosal-inflammation-expands-functional-polymorphonuclear-myeloid-derived-suppressor-cells-daan-k-j-pieren\/","title":{"rendered":"Cervical mucosal inflammation expands functional polymorphonuclear myeloid-derived suppressor cells. Daan K J Pieren"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Nov 17:S1933-0219(25)00125-4. doi: 10.1016\/j.mucimm.2025.11.008. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The mucosal immune system plays a fundamental role in maintaining microbial balance. Microbial imbalance in the female genital tract increases the risk for adverse health outcomes in women and may increase susceptibility to local infections. Myeloid-derived suppressor cells (MDSCs) remain understudied in the context of female genital tract conditions. Here we show that frequency of polymorphonuclear (PMN-) MDSCs increased in the cervical mucosa of women with Chlamydia trachomatis infection, bacterial vaginosis, or with a coinfection, but not in women with human papillomavirus infection. Mucosal PMN-MDSC frequencies correlated with mucosal IL-1\u03b2 in C. trachomatis patients and ex vivo exposure of cervical tissue to C. trachomatis elevated both PMN-MDSC frequencies and IL-1\u03b2 secretion. Likewise, exposure of cervical tissue to cervicovaginal lavage fluid from C. trachomatis and bacterial vaginosis patients also enhanced PMN-MDSC frequencies. Lastly, cervical MDSCs expressed suppressive mediators and functionally suppressed cytotoxic T-cell responses. Our study identifies IL-1\u03b2-stimulated PMN-MDSCs as immunosuppressive mediators in female genital tract infections, potentially modulating susceptibility to local secondary infections.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41260389\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20251120005109&amp;v=2.18.0.post22+67771e2\">41260389<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.11.008\">10.1016\/j.mucimm.2025.11.008<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Nov 17:S1933-0219(25)00125-4. doi: 10.1016\/j.mucimm.2025.11.008. Online ahead of print. ABSTRACT The mucosal immune system plays a fundamental role in maintaining microbial balance. Microbial imbalance in the female genital tract increases the risk for adverse health outcomes in women and may increase susceptibility to local infections. Myeloid-derived suppressor cells (MDSCs) remain understudied in the &#8230; <a title=\"Cervical mucosal inflammation expands functional polymorphonuclear myeloid-derived suppressor cells. Daan K J Pieren\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/20\/cervical-mucosal-inflammation-expands-functional-polymorphonuclear-myeloid-derived-suppressor-cells-daan-k-j-pieren\/\" aria-label=\"Read more about Cervical mucosal inflammation expands functional polymorphonuclear myeloid-derived suppressor cells. Daan K J Pieren\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-49176","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=49176"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49176\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=49176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=49176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=49176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}