{"id":49177,"date":"2025-11-20T06:51:12","date_gmt":"2025-11-20T05:51:12","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/20\/regulation-of-intestinal-injury-via-dietary-cysteine-francesco-siracusa\/"},"modified":"2025-11-20T06:51:12","modified_gmt":"2025-11-20T05:51:12","slug":"regulation-of-intestinal-injury-via-dietary-cysteine-francesco-siracusa","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/20\/regulation-of-intestinal-injury-via-dietary-cysteine-francesco-siracusa\/","title":{"rendered":"Regulation of intestinal injury via dietary cysteine. Francesco Siracusa"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Nov 19:S1471-4906(25)00286-8. doi: 10.1016\/j.it.2025.11.003. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8\u03b1\u03b2<sup>+<\/sup> T cells that secrete IL-22. This epithelial-immune crosstalk potentiates ISC repair after injury, highlighting a metabolism-immune axis linking cysteine sensing to tissue regeneration.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41260991\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251120005111&amp;v=2.18.0.post22+67771e2\">41260991<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.11.003\">10.1016\/j.it.2025.11.003<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Nov 19:S1471-4906(25)00286-8. doi: 10.1016\/j.it.2025.11.003. Online ahead of print. ABSTRACT Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8\u03b1\u03b2+ T cells that secrete IL-22. This epithelial-immune crosstalk potentiates ISC repair after injury, highlighting a metabolism-immune axis linking cysteine &#8230; <a title=\"Regulation of intestinal injury via dietary cysteine. Francesco Siracusa\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/20\/regulation-of-intestinal-injury-via-dietary-cysteine-francesco-siracusa\/\" aria-label=\"Read more about Regulation of intestinal injury via dietary cysteine. Francesco Siracusa\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-49177","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=49177"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49177\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=49177"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=49177"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=49177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}