{"id":49235,"date":"2025-11-21T06:28:56","date_gmt":"2025-11-21T05:28:56","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/21\/interleukin-22-the-hub-bridging-gut-homeostasis-and-metabolism-shupei-wang\/"},"modified":"2025-11-21T06:28:56","modified_gmt":"2025-11-21T05:28:56","slug":"interleukin-22-the-hub-bridging-gut-homeostasis-and-metabolism-shupei-wang","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/21\/interleukin-22-the-hub-bridging-gut-homeostasis-and-metabolism-shupei-wang\/","title":{"rendered":"Interleukin-22: the hub bridging gut homeostasis and metabolism. Shupei Wang"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Nov 19:S1471-4906(25)00253-4. doi: 10.1016\/j.it.2025.10.009. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>IL-22, produced by various cell types including T helper (Th) 17 cells and group 3 innate lymphoid cells (ILC3s), plays a pivotal role in gut homeostasis by acting on non-hematopoietic cells. It promotes epithelial barrier integrity, tissue repair, and antimicrobial defense. Beyond its established function in mucosal immunity, emerging evidence reveals IL-22&#8217;s involvement in regulating intestinal metabolism and protecting against systemic metabolic dysregulation. This review highlights recent advances in preclinical mouse models and human clinical data in IL-22 biology, focusing on its dual role in immune defense and metabolic control. Given the strong link between inflammatory bowel disease (IBD) and metabolic disorders, we further discuss IL-22&#8217;s therapeutic potential in mitigating both intestinal inflammation and related metabolic complications.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41266201\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251121002856&amp;v=2.18.0.post22+67771e2\">41266201<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.10.009\">10.1016\/j.it.2025.10.009<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Nov 19:S1471-4906(25)00253-4. doi: 10.1016\/j.it.2025.10.009. Online ahead of print. ABSTRACT IL-22, produced by various cell types including T helper (Th) 17 cells and group 3 innate lymphoid cells (ILC3s), plays a pivotal role in gut homeostasis by acting on non-hematopoietic cells. It promotes epithelial barrier integrity, tissue repair, and antimicrobial defense. Beyond its &#8230; <a title=\"Interleukin-22: the hub bridging gut homeostasis and metabolism. Shupei Wang\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/21\/interleukin-22-the-hub-bridging-gut-homeostasis-and-metabolism-shupei-wang\/\" aria-label=\"Read more about Interleukin-22: the hub bridging gut homeostasis and metabolism. Shupei Wang\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-49235","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49235","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=49235"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49235\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=49235"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=49235"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=49235"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}