{"id":49360,"date":"2025-11-23T07:06:04","date_gmt":"2025-11-23T06:06:04","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/11\/23\/role-of-il-10-signaling-in-the-circadian-control-of-host-response-to-influenza-infection-kaitlyn-m-forrest\/"},"modified":"2025-11-23T07:06:04","modified_gmt":"2025-11-23T06:06:04","slug":"role-of-il-10-signaling-in-the-circadian-control-of-host-response-to-influenza-infection-kaitlyn-m-forrest","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/11\/23\/role-of-il-10-signaling-in-the-circadian-control-of-host-response-to-influenza-infection-kaitlyn-m-forrest\/","title":{"rendered":"Role of IL-10 signaling in the circadian control of host response to influenza infection. Kaitlyn M Forrest"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2025 Nov 20:S1933-0219(25)00127-8. doi: 10.1016\/j.mucimm.2025.11.010. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>We have previously demonstrated that the circadian clock regulates the host response to influenza A virus (IAV) infection. While IL-10 is well-known for its immunoregulatory function, its role in IAV remains unclear, with studies reporting both protective and detrimental effects. Given the diurnal rhythmicity of IL-10 receptor (IL-10ra) expression in the lung, we investigated the contribution of IL-10 signaling to time-of-day-specific IAV protection. We found that blocking IL-10 signaling abrogated the time-of-day protection, leading to increased immunopathology characterized by enhanced lymphocyte infiltration and global immune activation (transcriptomic analysis). Interestingly, while later, IL-10R blockade also eliminated the time-of-day difference in IAV outcomes, it improved the outcome of dusk-infected mice. Furthermore, Natural Killer (NK) cell depletion suppressed IL-10 levels in bronchoalveolar lavage, suggesting a role for these cells in regulating IL-10 signaling. In conclusion, incorporating the circadian context has not only clarified the IL-10 role in IAV infection but also underscored the pivotal influence of circadian regulation on immune responses.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41274514\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20251123010602&amp;v=2.18.0.post22+67771e2\">41274514<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2025.11.010\">10.1016\/j.mucimm.2025.11.010<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2025 Nov 20:S1933-0219(25)00127-8. doi: 10.1016\/j.mucimm.2025.11.010. Online ahead of print. ABSTRACT We have previously demonstrated that the circadian clock regulates the host response to influenza A virus (IAV) infection. While IL-10 is well-known for its immunoregulatory function, its role in IAV remains unclear, with studies reporting both protective and detrimental effects. Given the diurnal &#8230; <a title=\"Role of IL-10 signaling in the circadian control of host response to influenza infection. Kaitlyn M Forrest\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/11\/23\/role-of-il-10-signaling-in-the-circadian-control-of-host-response-to-influenza-infection-kaitlyn-m-forrest\/\" aria-label=\"Read more about Role of IL-10 signaling in the circadian control of host response to influenza infection. Kaitlyn M Forrest\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-49360","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=49360"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/49360\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=49360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=49360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=49360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}