{"id":51088,"date":"2025-12-14T04:35:34","date_gmt":"2025-12-14T03:35:34","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/12\/14\/slc7a5-regulates-b-cell-metabolism-and-plasma-cell-differentiation-independent-of-leucine-transport\/"},"modified":"2025-12-14T04:35:34","modified_gmt":"2025-12-14T03:35:34","slug":"slc7a5-regulates-b-cell-metabolism-and-plasma-cell-differentiation-independent-of-leucine-transport","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/12\/14\/slc7a5-regulates-b-cell-metabolism-and-plasma-cell-differentiation-independent-of-leucine-transport\/","title":{"rendered":"SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2025 Dec 13:vkaf328. doi: 10.1093\/jimmun\/vkaf328. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>B cells play critical roles in humoral immunity to infection, vaccination, and autoimmunity. The differentiation of B cells into antibody-producing plasma cells (PCs) has been extensively studied, but the role of metabolic transporters that mediate nutrient uptake during PC differentiation is not well-understood. Here, we characterized the dependence of B cells and PC differentiation on the neutral amino acid transporter SLC7A5. We demonstrate that SLC7A5 promotes B cell functions including proliferation and PC differentiation in vitro and in vivo after immunization with T dependent and independent antigens. Deletion of SLC7A5 in B cells suppressed the function of mTORC1 and enforced mTORC1 activity rescued PC differentiation. The role of SLC7A5 in B cells appears to be unrelated to leucine uptake because B cells were insensitive to extracellular leucine depletion. Defects in SLC7A5-deficient B cells could, however, be rescued by extracellular methionine supplementation, suggesting a role for methionine in SLC7A5-dependent B cell function and PC differentiation. Our study provides evidence for a leucine-independent role of SLC7A5 in B cell function and PC differentiation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41389221\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20251213223533&amp;v=2.18.0.post22+67771e2\">41389221<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf328\">10.1093\/jimmun\/vkaf328<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2025 Dec 13:vkaf328. doi: 10.1093\/jimmun\/vkaf328. Online ahead of print. ABSTRACT B cells play critical roles in humoral immunity to infection, vaccination, and autoimmunity. The differentiation of B cells into antibody-producing plasma cells (PCs) has been extensively studied, but the role of metabolic transporters that mediate nutrient uptake during PC differentiation is not well-understood. &#8230; <a title=\"SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/14\/slc7a5-regulates-b-cell-metabolism-and-plasma-cell-differentiation-independent-of-leucine-transport\/\" aria-label=\"Read more about SLC7A5 regulates B cell metabolism and plasma cell differentiation independent of leucine transport\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-51088","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51088","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=51088"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51088\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=51088"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=51088"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=51088"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}