{"id":51089,"date":"2025-12-14T06:38:19","date_gmt":"2025-12-14T05:38:19","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/12\/14\/neuronal-inflammasomes-balancing-immunity-neuroinflammation-and-homeostasis-juan-pablo-de-rivero-vaccari\/"},"modified":"2025-12-14T06:38:19","modified_gmt":"2025-12-14T05:38:19","slug":"neuronal-inflammasomes-balancing-immunity-neuroinflammation-and-homeostasis-juan-pablo-de-rivero-vaccari","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/12\/14\/neuronal-inflammasomes-balancing-immunity-neuroinflammation-and-homeostasis-juan-pablo-de-rivero-vaccari\/","title":{"rendered":"Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis. Juan Pablo de Rivero Vaccari"},"content":{"rendered":"<div>\n<p><b>Trends Immunol<\/b>. 2025 Dec 12:S1471-4906(25)00306-0. doi: 10.1016\/j.it.2025.11.007. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Recent discoveries reveal that inflammasome signaling in neurons extends beyond host defense to influence fundamental aspects of brain function, including synaptic plasticity, axon remodeling, and exosome-mediated intercellular communication. This review explores how basal neuronal inflammasome activity contributes to central nervous system (CNS) homeostasis and how heightened signaling in neurons drives neuroinflammatory and degenerative processes. Understanding these dual roles of neuronal inflammasomes provides new insights into neuroimmune crosstalk and identifies potential targets for modulating repair and inflammation in CNS injury and disease.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41390307\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=100966032&amp;ff=20251214003818&amp;v=2.18.0.post22+67771e2\">41390307<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.it.2025.11.007\">10.1016\/j.it.2025.11.007<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Trends Immunol. 2025 Dec 12:S1471-4906(25)00306-0. doi: 10.1016\/j.it.2025.11.007. Online ahead of print. ABSTRACT Recent discoveries reveal that inflammasome signaling in neurons extends beyond host defense to influence fundamental aspects of brain function, including synaptic plasticity, axon remodeling, and exosome-mediated intercellular communication. This review explores how basal neuronal inflammasome activity contributes to central nervous system (CNS) homeostasis &#8230; <a title=\"Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis. Juan Pablo de Rivero Vaccari\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2025\/12\/14\/neuronal-inflammasomes-balancing-immunity-neuroinflammation-and-homeostasis-juan-pablo-de-rivero-vaccari\/\" aria-label=\"Read more about Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis. Juan Pablo de Rivero Vaccari\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-51089","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=51089"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51089\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=51089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=51089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=51089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}