{"id":51429,"date":"2025-12-18T07:50:51","date_gmt":"2025-12-18T06:50:51","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/12\/18\/immune-cellular-homeostasis-and-its-breakdown-at-the-maternal-fetal-interface-nardhy-gomez-lopez\/"},"modified":"2025-12-18T07:50:51","modified_gmt":"2025-12-18T06:50:51","slug":"immune-cellular-homeostasis-and-its-breakdown-at-the-maternal-fetal-interface-nardhy-gomez-lopez","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/12\/18\/immune-cellular-homeostasis-and-its-breakdown-at-the-maternal-fetal-interface-nardhy-gomez-lopez\/","title":{"rendered":"Immune cellular homeostasis and its breakdown at the maternal-fetal interface. Nardhy Gomez-Lopez"},"content":{"rendered":"
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Trends Immunol<\/b>. 2025 Dec 16:S1471-4906(25)00302-3. doi: 10.1016\/j.it.2025.11.006. Online ahead of print.<\/p>\n

ABSTRACT<\/b><\/p>\n

Pregnancy requires dynamic immune adaptations that balance tolerance, homeostasis, and defense at the maternal-fetal interface. Recent advances integrating findings from human placental samples with those from refined animal models now enable a detailed analysis of how cellular responses in mid and late gestation contribute to major obstetrical complications – with distinct clinical manifestations – such as preterm birth, fetal growth restriction, and pre-eclampsia. In this Opinion article we propose a unifying paradigm: the breakdown of maternal-fetal immune homeostasis. We highlight regulatory T cells and decidual macrophages as complementary regulators of antigen-specific tolerance and nonspecific homeostasis, whereas effector T cell infiltration in chronic placental inflammation and neutrophil-driven inflammation in acute chorioamnionitis exemplify pathological immune activation. Together, these examples illustrate how immune programs that sustain mid-to-late pregnancy, when dysregulated, drive pathology and open new therapeutic opportunities.<\/p>\n

PMID:41407649<\/a> | DOI:10.1016\/j.it.2025.11.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Trends Immunol. 2025 Dec 16:S1471-4906(25)00302-3. doi: 10.1016\/j.it.2025.11.006. Online ahead of print. ABSTRACT Pregnancy requires dynamic immune adaptations that balance tolerance, homeostasis, and defense at the maternal-fetal interface. Recent advances integrating findings from human placental samples with those from refined animal models now enable a detailed analysis of how cellular responses in mid and late gestation … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,68],"tags":[],"class_list":["post-51429","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-trends-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51429","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=51429"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51429\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=51429"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=51429"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=51429"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}