{"id":51658,"date":"2025-12-23T14:16:10","date_gmt":"2025-12-23T13:16:10","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2025\/12\/23\/il-36-mediates-immune-activation-in-sjogrens-disease-and-may-represent-a-novel-biomarker-of-diseasebayan-alhaddad-on-23-de-december-de-2025-at-1100\/"},"modified":"2025-12-23T14:16:10","modified_gmt":"2025-12-23T13:16:10","slug":"il-36-mediates-immune-activation-in-sjogrens-disease-and-may-represent-a-novel-biomarker-of-diseasebayan-alhaddad-on-23-de-december-de-2025-at-1100","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2025\/12\/23\/il-36-mediates-immune-activation-in-sjogrens-disease-and-may-represent-a-novel-biomarker-of-diseasebayan-alhaddad-on-23-de-december-de-2025-at-1100\/","title":{"rendered":"IL-36 mediates immune activation in Sj\u00f6gren’s disease and may represent a novel biomarker of disease\u200bBayan Alhaddad on 23 de December de 2025 at 11:00"},"content":{"rendered":"
\n

J Leukoc Biol<\/b>. 2025 Dec 22:qiaf183. doi: 10.1093\/jleuko\/qiaf183. Online ahead of print.<\/p>\n

ABSTRACT<\/b><\/p>\n

Sj\u00f6gren’s disease (SjD) is a systemic autoimmune disease. The underlying disease mechanisms remain poorly understood and there are no curative therapies. MyD88-mediated signaling is essential for SjD, although the pathways that rely on MyD88 are not well characterized. Our objective was to determine if MyD88-dependent IL-1 cytokines mediate inflammation in SjD. Using a SjD mouse model and patient samples, RNA-sequencing was performed on salivary tissue and peripheral B cells. Splenocytes from SjD mice were stimulated with IL-36 cytokines and B cell activation was assessed. Finally, ELISAs were employed to measure IL-36 in SjD patient sera. Our data revealed that IL-1 family-associated genes were dysregulated in SjD salivary tissue. Salivary B cells showed upregulation of genes associated with MyD88 and IL-36 activation and peripheral B cells from SjD mice had dysregulated IL-1 signaling networks. Moreover, B cells from SjD mice showed enhanced activation when stimulated with IL-36 cytokines, and splenocytes derived from SjD mice exhibited elevated cytokine secretion. Finally, high levels of IL-36\u03b1 and IL-36\u03b3 were present in SjD patient sera and IL-36\u03b1 levels discriminated SjD patients from non-SjD controls. Therefore, IL-36 contributes to disease and drugs targeting IL-1 cytokines, particularly IL-36, may represent novel therapeutic targets for SjD.<\/p>\n

PMID:41430745<\/a> | DOI:10.1093\/jleuko\/qiaf183<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Leukoc Biol. 2025 Dec 22:qiaf183. doi: 10.1093\/jleuko\/qiaf183. Online ahead of print. ABSTRACT Sj\u00f6gren’s disease (SjD) is a systemic autoimmune disease. The underlying disease mechanisms remain poorly understood and there are no curative therapies. MyD88-mediated signaling is essential for SjD, although the pathways that rely on MyD88 are not well characterized. Our objective was to … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-51658","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=51658"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51658\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=51658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=51658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=51658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}