{"id":51837,"date":"2026-01-02T07:23:19","date_gmt":"2026-01-02T06:23:19","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/02\/characterizing-immune-cell-profiles-of-patients-with-rheumatoid-arthritis-in-taiwan-using-artificial-intelligence-based-cytometric-approachespo-yu-li-on-1-de-january-de-2026-at-1100\/"},"modified":"2026-01-02T07:23:19","modified_gmt":"2026-01-02T06:23:19","slug":"characterizing-immune-cell-profiles-of-patients-with-rheumatoid-arthritis-in-taiwan-using-artificial-intelligence-based-cytometric-approachespo-yu-li-on-1-de-january-de-2026-at-1100","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/02\/characterizing-immune-cell-profiles-of-patients-with-rheumatoid-arthritis-in-taiwan-using-artificial-intelligence-based-cytometric-approachespo-yu-li-on-1-de-january-de-2026-at-1100\/","title":{"rendered":"Characterizing immune cell profiles of patients with rheumatoid arthritis in Taiwan using artificial intelligence-based cytometric approaches\u200bPo-Yu Li   on 1 de January de 2026 at 11:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Jan 2:qiaf188. doi: 10.1093\/jleuko\/qiaf188. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell proportions of 104 subsets across granulocyte, T-cell, B-cell, and innate lineages were profiled by flow cytometry in 21 new-onset RA patients and 21 healthy controls. Non-parametric tests compared groups, followed by training a logistic regression-based AI model with cross-validation to characterize RA immune profiles and assess each subset&#8217;s contribution. Among 104 immune cell subsets analyzed, 16 were indicative of RA. Increased proportions of marginal zone B cells, IgMhi B cells, CD11b+lineage- cells, monocytes, and MHC II+ monocytes, along with decreased eosinophils, reflected activation of innate and humoral immune responses in RA patients. Elevated levels of FoxP3+CD4+ regulatory T cells (FoxP3+ CD4 Treg) and their CTLA4+ subset, as well as increased MHC II+CD4+ and CD8+ T cells, PD-L1+ NK cells, and PD-L1+CD8+ NKT cells, suggested a compensatory immune response. The AI model distinguished immune profiles between RA patients and healthy controls with 100% sensitivity and specificity in this dataset, identifying RA by lower MHC II+ monocytes, higher CTLA4+ CD4 Treg cells, and elevated monocytes. These findings demonstrate the potential of using ICP hallmarks to develop novel diagnostic tools and therapeutic strategies for RA.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41479108\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260102012319&amp;v=2.18.0.post22+67771e2\">41479108<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiaf188\">10.1093\/jleuko\/qiaf188<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Jan 2:qiaf188. doi: 10.1093\/jleuko\/qiaf188. Online ahead of print. ABSTRACT Changes in specific immune cell lineages, such as T and B cells, play a central role in the pathogenesis of rheumatoid arthritis (RA). However, a comprehensive evaluation of systemic immune cell changes in RA remains limited. Immune cell proportions of 104 subsets &#8230; <a title=\"Characterizing immune cell profiles of patients with rheumatoid arthritis in Taiwan using artificial intelligence-based cytometric approaches\u200bPo-Yu Li   on 1 de January de 2026 at 11:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/02\/characterizing-immune-cell-profiles-of-patients-with-rheumatoid-arthritis-in-taiwan-using-artificial-intelligence-based-cytometric-approachespo-yu-li-on-1-de-january-de-2026-at-1100\/\" aria-label=\"Read more about Characterizing immune cell profiles of patients with rheumatoid arthritis in Taiwan using artificial intelligence-based cytometric approaches\u200bPo-Yu Li   on 1 de January de 2026 at 11:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-51837","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=51837"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/51837\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=51837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=51837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=51837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}