{"id":52559,"date":"2026-01-10T06:39:03","date_gmt":"2026-01-10T05:39:03","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/10\/trained-ilc2-prevent-il-17-associated-lung-injury-during-helminth-infection-through-a-serotonin-dependent-mechanism-ulrich-membe-femoe\/"},"modified":"2026-01-10T06:39:03","modified_gmt":"2026-01-10T05:39:03","slug":"trained-ilc2-prevent-il-17-associated-lung-injury-during-helminth-infection-through-a-serotonin-dependent-mechanism-ulrich-membe-femoe","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/10\/trained-ilc2-prevent-il-17-associated-lung-injury-during-helminth-infection-through-a-serotonin-dependent-mechanism-ulrich-membe-femoe\/","title":{"rendered":"Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism. Ulrich Membe Femoe"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jan 7:S1933-0219(26)00002-4. doi: 10.1016\/j.mucimm.2026.01.002. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Type 2 cytokinerelease promotes wound healing and helminth clearance, but it remains unclearwhethergroup 2 innate lymphocytes (ILC2s) and T-helper2 cells (T<sub>H<\/sub>2) cells have functionally distinctroles during anamnestic immunity. This study demonstrates that ILC2 can prevent re-infection andlimit tissue injury caused by the helminthNippostrongylus brasiliensis (Nb). T<sub>H<\/sub>2 cells were necessary during initial antigen encounter but dispensable forearly pathogen clearance and lungrepairafterILC2 priming. Upon re-infection, trained ILC2 selectively blocked interleukin (IL)-17+ \u03b3\u03b4T cell expansion and infection-induced lung injury through an Amphiregulin (Areg)-independent mechanism. Trained ILC2s had a distinct metabolic gene expression profile marked by elevated tryptophan hydroxylase 1(Tph1) and pulmonary serotonin levels were largely ILC2-dependent. Surprisingly, serotonin prevented IL-17-associated lung hemorrhage irrespective of parasite load. We propose that T<sub>H<\/sub>2-ILC2 interactions drive pathogen control, but ILC2 distinctly control lung tissuerepairthrough serotonin.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41513004\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260110003902&amp;v=2.18.0.post22+67771e2\">41513004<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.01.002\">10.1016\/j.mucimm.2026.01.002<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jan 7:S1933-0219(26)00002-4. doi: 10.1016\/j.mucimm.2026.01.002. Online ahead of print. ABSTRACT Type 2 cytokinerelease promotes wound healing and helminth clearance, but it remains unclearwhethergroup 2 innate lymphocytes (ILC2s) and T-helper2 cells (TH2) cells have functionally distinctroles during anamnestic immunity. This study demonstrates that ILC2 can prevent re-infection andlimit tissue injury caused by the helminthNippostrongylus &#8230; <a title=\"Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism. Ulrich Membe Femoe\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/10\/trained-ilc2-prevent-il-17-associated-lung-injury-during-helminth-infection-through-a-serotonin-dependent-mechanism-ulrich-membe-femoe\/\" aria-label=\"Read more about Trained ILC2 prevent IL-17-associated lung injury during helminth infection through a serotonin-dependent mechanism. Ulrich Membe Femoe\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-52559","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/52559","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=52559"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/52559\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=52559"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=52559"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=52559"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}