{"id":53814,"date":"2026-01-16T23:47:47","date_gmt":"2026-01-16T22:47:47","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/16\/diverse-il-9-secreting-t-helper-cells-direct-responses-in-the-allergic-lung-kaitlyn-g-jackson\/"},"modified":"2026-01-16T23:47:47","modified_gmt":"2026-01-16T22:47:47","slug":"diverse-il-9-secreting-t-helper-cells-direct-responses-in-the-allergic-lung-kaitlyn-g-jackson","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/16\/diverse-il-9-secreting-t-helper-cells-direct-responses-in-the-allergic-lung-kaitlyn-g-jackson\/","title":{"rendered":"Diverse IL-9-secreting T helper cells direct responses in the allergic lung. Kaitlyn G Jackson"},"content":{"rendered":"<div>\n<p><b>Semin Immunol<\/b>. 2026 Jan 14;81:102014. doi: 10.1016\/j.smim.2026.102014. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease. IL-9 has increasingly been linked to asthma severity in patients. Early studies primarily focused on the differentiation of &#8220;classical&#8221; Th9 cells, which express IL-9 but not other type II cytokines. Recent research has identified additional populations of IL-9-secreting CD4<sup>+<\/sup> T cells, including Th2-allergic (Th2A) cells and resident memory Th9 (Th9rm) cells. Despite IL-9 induction in classical Th9 effector cells being transient, Th2A and memory populations generate a recall IL-9 response upon repeated allergen exposure. Additionally, cytokine-driven bystander activation may prolong IL-9 production in various CD4<sup>+<\/sup> T cell subsets. This review evaluates the transcriptional, metabolic, and cytokine-mediated signals that regulate the effector function of IL-9-secreting CD4<sup>+<\/sup> T cell subsets in models of acute, chronic, and intermittent allergic airway disease. Given the heterogeneity of asthma phenotypes, identifying endotypes characterized by high levels of Th9 cells or IL-9 may improve therapeutic precision in asthma treatment.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41539200\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=9009458&amp;ff=20260116174746&amp;v=2.18.0.post22+67771e2\">41539200<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.smim.2026.102014\">10.1016\/j.smim.2026.102014<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Semin Immunol. 2026 Jan 14;81:102014. doi: 10.1016\/j.smim.2026.102014. Online ahead of print. ABSTRACT IL-9 promotes airway hyperresponsiveness, eosinophilia, mast cell expansion, and antibody-mediated inflammation through interactions with mast cells, eosinophils, B cells, and airway and lung macrophages in models of allergic airway disease. IL-9 has increasingly been linked to asthma severity in patients. Early studies primarily &#8230; <a title=\"Diverse IL-9-secreting T helper cells direct responses in the allergic lung. Kaitlyn G Jackson\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/16\/diverse-il-9-secreting-t-helper-cells-direct-responses-in-the-allergic-lung-kaitlyn-g-jackson\/\" aria-label=\"Read more about Diverse IL-9-secreting T helper cells direct responses in the allergic lung. Kaitlyn G Jackson\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,110],"tags":[],"class_list":["post-53814","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-seminars-in-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/53814","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=53814"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/53814\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=53814"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=53814"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=53814"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}