{"id":53936,"date":"2026-01-20T07:22:09","date_gmt":"2026-01-20T06:22:09","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/20\/single-cell-atlas-of-lung-resident-innate-lymphoid-cells-shows-impact-of-age-and-dysbiosis-on-epigenetic-and-transcriptomic-programming-madeline-bonfield\/"},"modified":"2026-01-20T07:22:09","modified_gmt":"2026-01-20T06:22:09","slug":"single-cell-atlas-of-lung-resident-innate-lymphoid-cells-shows-impact-of-age-and-dysbiosis-on-epigenetic-and-transcriptomic-programming-madeline-bonfield","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/20\/single-cell-atlas-of-lung-resident-innate-lymphoid-cells-shows-impact-of-age-and-dysbiosis-on-epigenetic-and-transcriptomic-programming-madeline-bonfield\/","title":{"rendered":"Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming. Madeline Bonfield"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jan 17:S1933-0219(26)00004-8. doi: 10.1016\/j.mucimm.2026.01.004. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The mechanisms underlying innate lymphoid cell (ILC) development and function in the neonatal lung remain incompletely defined. ILCs are critical mediators of early-life innate immune responses in the lung. Dysregulation of ILC homeostasis has both immediate and long-lasting effects on lung health. We generated single-cell transcriptomic and epigenetic datasets from the lungs of neonatal and young adult mice that includes subsets of type 1 (natural killer, NK cells) type 2 (ILC2) and type 3 (ILC3) cells. These datasets include mice subjected to early life antibiotic-induced dysbiosis, thereby modeling a common perturbation of the developing immune system in humans. Analysis of cell-cell communication and gene regulation in these datasets reveals underappreciated aspects of lung ILC biology, including marked interleukin-4 (IL-4) signaling in neonatal lung ILC2. This data represents a valuable resource for hypothesis generation regarding the molecular regulation of ILC gene expression and function in the neonatal lung.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41554380\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260120012208&amp;v=2.18.0.post22+67771e2\">41554380<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.01.004\">10.1016\/j.mucimm.2026.01.004<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jan 17:S1933-0219(26)00004-8. doi: 10.1016\/j.mucimm.2026.01.004. Online ahead of print. ABSTRACT The mechanisms underlying innate lymphoid cell (ILC) development and function in the neonatal lung remain incompletely defined. ILCs are critical mediators of early-life innate immune responses in the lung. Dysregulation of ILC homeostasis has both immediate and long-lasting effects on lung health. We &#8230; <a title=\"Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming. Madeline Bonfield\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/20\/single-cell-atlas-of-lung-resident-innate-lymphoid-cells-shows-impact-of-age-and-dysbiosis-on-epigenetic-and-transcriptomic-programming-madeline-bonfield\/\" aria-label=\"Read more about Single cell atlas of lung-resident innate lymphoid cells shows impact of age and dysbiosis on epigenetic and transcriptomic programming. Madeline Bonfield\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-53936","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/53936","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=53936"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/53936\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=53936"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=53936"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=53936"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}