{"id":54184,"date":"2026-01-23T07:17:07","date_gmt":"2026-01-23T06:17:07","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/23\/neuronal-vip-wires-the-intestinal-epithelial-cell-function-ziad-al-nabhani\/"},"modified":"2026-01-23T07:17:07","modified_gmt":"2026-01-23T06:17:07","slug":"neuronal-vip-wires-the-intestinal-epithelial-cell-function-ziad-al-nabhani","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/23\/neuronal-vip-wires-the-intestinal-epithelial-cell-function-ziad-al-nabhani\/","title":{"rendered":"Neuronal VIP wires the intestinal epithelial cell function. Ziad Al Nabhani"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Jan 20:S1933-0219(26)00006-1. doi: 10.1016\/j.mucimm.2026.01.006. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type 2 immunity, and establishes a neuro-epithelial circuit preserving gut barrier integrity.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41571149\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260123011706&amp;v=2.18.0.post22+67771e2\">41571149<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.01.006\">10.1016\/j.mucimm.2026.01.006<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Jan 20:S1933-0219(26)00006-1. doi: 10.1016\/j.mucimm.2026.01.006. Online ahead of print. ABSTRACT Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type &#8230; <a title=\"Neuronal VIP wires the intestinal epithelial cell function. Ziad Al Nabhani\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/23\/neuronal-vip-wires-the-intestinal-epithelial-cell-function-ziad-al-nabhani\/\" aria-label=\"Read more about Neuronal VIP wires the intestinal epithelial cell function. Ziad Al Nabhani\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-54184","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/54184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=54184"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/54184\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=54184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=54184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=54184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}