{"id":54440,"date":"2026-01-27T12:00:00","date_gmt":"2026-01-27T11:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/a-case-based-literature-review-of-rela-associated-inflammatory-diseases\/"},"modified":"2026-01-27T12:00:00","modified_gmt":"2026-01-27T11:00:00","slug":"a-case-based-literature-review-of-rela-associated-inflammatory-diseases","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/a-case-based-literature-review-of-rela-associated-inflammatory-diseases\/","title":{"rendered":"A Case-Based Literature Review of RELA Associated Inflammatory Diseases"},"content":{"rendered":"<div>\n<p><b>J Clin Immunol<\/b>. 2026 Jan 27. doi: 10.1007\/s10875-025-01968-x. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Beh\u00e7et&#8217;s disease (BD) is a chronic inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, skin lesions, and uveitis. Recent genetic studies have identified monogenic diseases with phenotypes resembling BD, including RELA-associated inflammatory disease (RAID), Haploinsufficiency of A20 (HA20), and otulipenia. The RelA gene encodes the RELA protein, which is involved in the nuclear factor kappa B (NF-\u03baB) signaling pathway that regulates the transcription of genes associated with cell survival, apoptosis, and immune responses. In RAID, dysfunction of the NF-\u03baB pathway leads to reduced cell survival and symptoms of BD, such as recurrent fever, chronic mucocutaneous ulceration, arthralgia, and colitis. Herein, we report a pediatric patient who presented with recurrent, severe oral and genital ulcers from the age of five years and was diagnosed with RAID following a documented RelA gene mutation. The patient responded to a combination of corticosteroids, colchicine and methotrexate. RAID should be considered in the differential diagnosis of patients with early onset recurrent fever and mucosal ulcerations.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41591550\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20260127133455&amp;v=2.18.0.post22+67771e2\">41591550<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-025-01968-x\">10.1007\/s10875-025-01968-x<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2026 Jan 27. doi: 10.1007\/s10875-025-01968-x. Online ahead of print. ABSTRACT Beh\u00e7et&#8217;s disease (BD) is a chronic inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, skin lesions, and uveitis. Recent genetic studies have identified monogenic diseases with phenotypes resembling BD, including RELA-associated inflammatory disease (RAID), Haploinsufficiency of A20 (HA20), and otulipenia. &#8230; <a title=\"A Case-Based Literature Review of RELA Associated Inflammatory Diseases\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/27\/a-case-based-literature-review-of-rela-associated-inflammatory-diseases\/\" aria-label=\"Read more about A Case-Based Literature Review of RELA Associated Inflammatory Diseases\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-54440","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/54440","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=54440"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/54440\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=54440"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=54440"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=54440"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}