{"id":54693,"date":"2026-01-30T01:23:11","date_gmt":"2026-01-30T00:23:11","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/01\/30\/non-eosinophilic-leukolectin-proteins-occur-in-cytoplasmic-granules-in-some-human-leukocytesmirushe-h-miftari-on-29-de-january-de-2026-at-1100\/"},"modified":"2026-01-30T01:23:11","modified_gmt":"2026-01-30T00:23:11","slug":"non-eosinophilic-leukolectin-proteins-occur-in-cytoplasmic-granules-in-some-human-leukocytesmirushe-h-miftari-on-29-de-january-de-2026-at-1100","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/01\/30\/non-eosinophilic-leukolectin-proteins-occur-in-cytoplasmic-granules-in-some-human-leukocytesmirushe-h-miftari-on-29-de-january-de-2026-at-1100\/","title":{"rendered":"Non-eosinophilic leukolectin-proteins occur in cytoplasmic granules in some human leukocytes\u200bMirushe H Miftari   on 29 de January de 2026 at 11:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Jan 29:qiag012. doi: 10.1093\/jleuko\/qiag012. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Novel leukolectin-proteins (LL-proteins) are present in multiple lower vertebrates. LL-proteins (\u223c255 AAs) possess five TECPR-domains spanning 4\/5 of conserved AA-sequences, and are detected in dermal lectocytes, (primitive and tissue resident) macrophages and some leukocytes. Hatched fish embryos employ secreted LL-proteins for innate immunity-defense. LL-genes display 4 introns, 5 exons and multiple 5&#8242;-upstream binding-sites for hematopoietic transcription-factors. This study aims to identify potential LL-proteins in human leukocytes. Western-blots of protein-extracts (resolved by 2D-PAGE) exclusively revealed LL-proteins (MW \u0334\u033430 kD; pI \u03346.0), but only in PolymorphprepTM-enriched leukocytes, and not in LymphoprepTM-enriched leukocytes. Single-label immuno-fluorescence demonstrated LL-proteins in some PMN-leukocytes. Dual-label immuno-fluorescence corroborated LL-coexpression in some myeloperoxidase-positive neutrophils (denoted lectophils). Intervillous spaces in Caesarean placentas displayed both lectophils and large lectophils without well-defined PMN-nuclei. Some moderately LL-positive placental endothelium appeared to cytodifferentiate with intensified LL-expression to large, non-PMN lectophils for circulation. Functional distinctions between non-lectophilic neutrophils and lectophilic neutrophils await experimental delineation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41610142\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260129192307&amp;v=2.18.0.post22+67771e2\">41610142<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag012\">10.1093\/jleuko\/qiag012<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Jan 29:qiag012. doi: 10.1093\/jleuko\/qiag012. Online ahead of print. ABSTRACT Novel leukolectin-proteins (LL-proteins) are present in multiple lower vertebrates. LL-proteins (\u223c255 AAs) possess five TECPR-domains spanning 4\/5 of conserved AA-sequences, and are detected in dermal lectocytes, (primitive and tissue resident) macrophages and some leukocytes. Hatched fish embryos employ secreted LL-proteins for innate &#8230; <a title=\"Non-eosinophilic leukolectin-proteins occur in cytoplasmic granules in some human leukocytes\u200bMirushe H Miftari   on 29 de January de 2026 at 11:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/01\/30\/non-eosinophilic-leukolectin-proteins-occur-in-cytoplasmic-granules-in-some-human-leukocytesmirushe-h-miftari-on-29-de-january-de-2026-at-1100\/\" aria-label=\"Read more about Non-eosinophilic leukolectin-proteins occur in cytoplasmic granules in some human leukocytes\u200bMirushe H Miftari   on 29 de January de 2026 at 11:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-54693","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/54693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=54693"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/54693\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=54693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=54693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=54693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}