{"id":55060,"date":"2026-02-04T18:17:54","date_gmt":"2026-02-04T17:17:54","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/02\/04\/interferon-stimulation-and-nkg2d-expression-drive-enhanced-natural-killer-cell-antibody-dependent-cellular-cytotoxicity-against-viral-infectionsleslie-chan-on-4-de-february-de-2026-at-1100\/"},"modified":"2026-02-04T18:17:54","modified_gmt":"2026-02-04T17:17:54","slug":"interferon-stimulation-and-nkg2d-expression-drive-enhanced-natural-killer-cell-antibody-dependent-cellular-cytotoxicity-against-viral-infectionsleslie-chan-on-4-de-february-de-2026-at-1100","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/02\/04\/interferon-stimulation-and-nkg2d-expression-drive-enhanced-natural-killer-cell-antibody-dependent-cellular-cytotoxicity-against-viral-infectionsleslie-chan-on-4-de-february-de-2026-at-1100\/","title":{"rendered":"Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections\u200bLeslie Chan   on 4 de February de 2026 at 11:00"},"content":{"rendered":"<div>\n<p><b>J Leukoc Biol<\/b>. 2026 Feb 4:qiag019. doi: 10.1093\/jleuko\/qiag019. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) contributes to effective antiviral immunity, yet the relative contribution of NK cell-intrinsic factors and antibodies in mediating these responses remain poorly understood. Here, we combined functional ADCC assays with single-cell transcriptomics of peripheral NK cells from COVID-19 participants. Our analysis revealed distinct transcriptional programs between participants with different ADCC response levels: NK cells from participants with lower ADCC responses upregulated proliferation pathways, while those with high ADCC responses showed enhanced expression of interferon-stimulated genes and NKG2D. Blocking NKG2D significantly reduced NK cell ADCC degranulation and cytokine responses. Paradoxically, greater interferon-mediated NK cell activation was associated with reduced proficiency of participants&#8217; antibodies to mediate ADCC, suggesting a regulatory checkpoint mechanism. These findings enhance our understanding of the molecular determinants of ADCC responses and provide novel insights into leveraging these responses for more effective vaccination and therapeutic strategies.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41634919\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8405628&amp;ff=20260204121750&amp;v=2.18.0.post22+67771e2\">41634919<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jleuko\/qiag019\">10.1093\/jleuko\/qiag019<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Leukoc Biol. 2026 Feb 4:qiag019. doi: 10.1093\/jleuko\/qiag019. Online ahead of print. ABSTRACT Natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) contributes to effective antiviral immunity, yet the relative contribution of NK cell-intrinsic factors and antibodies in mediating these responses remain poorly understood. Here, we combined functional ADCC assays with single-cell transcriptomics of peripheral NK &#8230; <a title=\"Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections\u200bLeslie Chan   on 4 de February de 2026 at 11:00\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/04\/interferon-stimulation-and-nkg2d-expression-drive-enhanced-natural-killer-cell-antibody-dependent-cellular-cytotoxicity-against-viral-infectionsleslie-chan-on-4-de-february-de-2026-at-1100\/\" aria-label=\"Read more about Interferon stimulation and NKG2D expression drive enhanced natural killer cell antibody-dependent cellular cytotoxicity against viral infections\u200bLeslie Chan   on 4 de February de 2026 at 11:00\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-55060","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/55060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=55060"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/55060\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=55060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=55060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=55060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}