{"id":55184,"date":"2026-02-06T07:19:46","date_gmt":"2026-02-06T06:19:46","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/expression-of-cd103-facilitates-localization-and-activation-of-cd4-t-cells-within-mycobacterium-tuberculosis-lung-lesions-thomas-lindenstrom\/"},"modified":"2026-02-06T07:19:46","modified_gmt":"2026-02-06T06:19:46","slug":"expression-of-cd103-facilitates-localization-and-activation-of-cd4-t-cells-within-mycobacterium-tuberculosis-lung-lesions-thomas-lindenstrom","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/expression-of-cd103-facilitates-localization-and-activation-of-cd4-t-cells-within-mycobacterium-tuberculosis-lung-lesions-thomas-lindenstrom\/","title":{"rendered":"Expression of CD103 facilitates localization and activation of CD4+ T cells within Mycobacterium tuberculosis lung-lesions. Thomas Lindenstr\u00f8m"},"content":{"rendered":"<div>\n<p><b>Mucosal Immunol<\/b>. 2026 Feb 3:S1933-0219(26)00014-0. doi: 10.1016\/j.mucimm.2026.02.001. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The spatial localization of CD4+ T cells within the Mycobacterium tuberculosis (Mtb)-infected lung is critical for optimal immunity. Here, we investigate the role of two E-cadherin binding receptors, CD103 and KLRG1. We demonstrate that KLRG1 restricts CD4+ T cells to the lung vasculature early during infection, and limits lesion homing at chronic stages. Subunit vaccination diminishes KLRG1 expression and increases CD103+ CD4+ T cells associated with improved bacterial control. We identify a link between CD103 expression and Th17 differentiation, as vaccine-induced Th17 cells display increased propensity to upregulate CD103 in the lung. Mixed bone marrow chimeras reveal that CD103 promotes tissue retention and localization of CD4+ T cells in close proximity to Mtb, facilitating enhanced TCR signaling. In contrast, CD103-deficient cells remain confined to the lesion periphery with decreased TCR activation. These findings highlight the importance of CD103 in CD4+ T cell localization and antigen-sensing with implications for vaccine design.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41643900\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=101299742&amp;ff=20260206011941&amp;v=2.18.0.post22+67771e2\">41643900<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.mucimm.2026.02.001\">10.1016\/j.mucimm.2026.02.001<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mucosal Immunol. 2026 Feb 3:S1933-0219(26)00014-0. doi: 10.1016\/j.mucimm.2026.02.001. Online ahead of print. ABSTRACT The spatial localization of CD4+ T cells within the Mycobacterium tuberculosis (Mtb)-infected lung is critical for optimal immunity. Here, we investigate the role of two E-cadherin binding receptors, CD103 and KLRG1. We demonstrate that KLRG1 restricts CD4+ T cells to the lung vasculature &#8230; <a title=\"Expression of CD103 facilitates localization and activation of CD4+ T cells within Mycobacterium tuberculosis lung-lesions. Thomas Lindenstr\u00f8m\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/06\/expression-of-cd103-facilitates-localization-and-activation-of-cd4-t-cells-within-mycobacterium-tuberculosis-lung-lesions-thomas-lindenstrom\/\" aria-label=\"Read more about Expression of CD103 facilitates localization and activation of CD4+ T cells within Mycobacterium tuberculosis lung-lesions. Thomas Lindenstr\u00f8m\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[57,42],"tags":[],"class_list":["post-55184","post","type-post","status-publish","format-standard","hentry","category-mucosal-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/55184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=55184"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/55184\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=55184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=55184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=55184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}