{"id":55935,"date":"2026-02-11T12:00:00","date_gmt":"2026-02-11T11:00:00","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/02\/11\/was-protein-deficiency-disrupts-memory-b-cell-formation-during-acute-lcmv-infection\/"},"modified":"2026-02-11T12:00:00","modified_gmt":"2026-02-11T11:00:00","slug":"was-protein-deficiency-disrupts-memory-b-cell-formation-during-acute-lcmv-infection","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/02\/11\/was-protein-deficiency-disrupts-memory-b-cell-formation-during-acute-lcmv-infection\/","title":{"rendered":"WAS Protein Deficiency Disrupts Memory B Cell Formation During Acute LCMV Infection"},"content":{"rendered":"<div>\n<p><b>J Clin Immunol<\/b>. 2026 Feb 11. doi: 10.1007\/s10875-026-01984-5. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Wiskott-Aldrich syndrome (WAS) is a rare x-linked monogenic immunodeficiency disease, caused by the mutation of WAS gene encoding WAS protein (WASp). Previous findings in WAS patients show B cell perturbations in the periphery, characterized by diminished B-cell numbers and phenotype abnormalities, including reduced frequency of classical CD27<sup>+<\/sup> memory B cells (MBCs), accompanied by an unusual expansion of atypical CD21low MBCs. The mechanism underlying these abnormalities in MBCs developmental pathway has not been completely dissected. In this study, WASp knock-out mice undergone with acute lymphocytic choriomeningitis virus (LCMV) infection was used as a model to investigate the effects of WASp deficiency on the differentiation of MBCs and the possible mechanisms. We found that by day 11 after infection, the proportion of classical IgG2c<sup>+<\/sup> MBCs was dramatically decreased, this was accompanied by a corresponding increase in the proportion of atypical CD21low MBCs. Using single-cell RNA sequencing (scRNA-seq), we also identified WASp deficiency promoted the formation of atypical MBCs during acute viral infection. Remarkably, our study revealed a marked reduction of WASp expression in atypical MBCs. Overall, our data show that WASp is differentially expressed in MBCs subsets, and manipulates the fate of MBCs during acute LCMV infection.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41670926\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_campaign=journals&amp;utm_content=8102137&amp;ff=20260211131106&amp;v=2.18.0.post22+67771e2\">41670926<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1007\/s10875-026-01984-5\">10.1007\/s10875-026-01984-5<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Clin Immunol. 2026 Feb 11. doi: 10.1007\/s10875-026-01984-5. Online ahead of print. ABSTRACT Wiskott-Aldrich syndrome (WAS) is a rare x-linked monogenic immunodeficiency disease, caused by the mutation of WAS gene encoding WAS protein (WASp). Previous findings in WAS patients show B cell perturbations in the periphery, characterized by diminished B-cell numbers and phenotype abnormalities, including &#8230; <a title=\"WAS Protein Deficiency Disrupts Memory B Cell Formation During Acute LCMV Infection\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/11\/was-protein-deficiency-disrupts-memory-b-cell-formation-during-acute-lcmv-infection\/\" aria-label=\"Read more about WAS Protein Deficiency Disrupts Memory B Cell Formation During Acute LCMV Infection\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69,42],"tags":[],"class_list":["post-55935","post","type-post","status-publish","format-standard","hentry","category-journal-of-clinical-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/55935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=55935"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/55935\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=55935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=55935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=55935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}