{"id":56334,"date":"2026-02-15T06:46:45","date_gmt":"2026-02-15T05:46:45","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/02\/15\/trpm7-channel-kinase-in-immunity-new-frontiers-of-an-emerging-therapeutic-target\/"},"modified":"2026-02-15T06:46:45","modified_gmt":"2026-02-15T05:46:45","slug":"trpm7-channel-kinase-in-immunity-new-frontiers-of-an-emerging-therapeutic-target","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/02\/15\/trpm7-channel-kinase-in-immunity-new-frontiers-of-an-emerging-therapeutic-target\/","title":{"rendered":"TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target"},"content":{"rendered":"<div>\n<p><b>Curr Opin Immunol<\/b>. 2026 Feb 13;99:102734. doi: 10.1016\/j.coi.2026.102734. Online ahead of print.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>The cation channel and protein kinase transient receptor potential cation channel subfamily M member 7 (TRPM7) has been linked to immune homeostasis, immune cell signaling and differentiation, and inflammatory diseases. Its importance in guiding ion-mediated cellular responses, funneling discrete kinase signal transduction events, and contributing to complex membrane-localized protein networks positions the channel-kinase as a promising pharmacological target. Diseases with underlying exacerbation of ion-coupled cellular responses are in focus. Undoubtedly, the manifold cells of the immune system undertake a key position in their demand for a smoothly adaptable molecular performance, reacting to incorporate environmental and nutritional triggers to guide diverse cellular states. We here discuss a current view of the molecular principles underlying TRPM7 function in immunity and provide a grasping outlook on open questions and research topics we expect to emerge in the upcoming years, positioning TRPM7 as an unattended player at the forefront of immune regulation.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41689941\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=8900118&amp;ff=20260215004638&amp;v=2.18.0.post22+67771e2\">41689941<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.coi.2026.102734\">10.1016\/j.coi.2026.102734<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Curr Opin Immunol. 2026 Feb 13;99:102734. doi: 10.1016\/j.coi.2026.102734. Online ahead of print. ABSTRACT The cation channel and protein kinase transient receptor potential cation channel subfamily M member 7 (TRPM7) has been linked to immune homeostasis, immune cell signaling and differentiation, and inflammatory diseases. Its importance in guiding ion-mediated cellular responses, funneling discrete kinase signal transduction &#8230; <a title=\"TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/02\/15\/trpm7-channel-kinase-in-immunity-new-frontiers-of-an-emerging-therapeutic-target\/\" aria-label=\"Read more about TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-56334","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/56334","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=56334"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/56334\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=56334"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=56334"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=56334"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}