{"id":56488,"date":"2026-02-18T06:55:56","date_gmt":"2026-02-18T05:55:56","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/02\/18\/t-cells-in-sjogrens-disease-update-on-their-role-in-salivary-gland-pathogenesis-and-treatment\/"},"modified":"2026-02-18T06:55:56","modified_gmt":"2026-02-18T05:55:56","slug":"t-cells-in-sjogrens-disease-update-on-their-role-in-salivary-gland-pathogenesis-and-treatment","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/02\/18\/t-cells-in-sjogrens-disease-update-on-their-role-in-salivary-gland-pathogenesis-and-treatment\/","title":{"rendered":"T cells in Sj\u00f6gren’s disease: update on their role in salivary gland pathogenesis and treatment"},"content":{"rendered":"
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Curr Opin Immunol<\/b>. 2026 Feb 16;99:102739. doi: 10.1016\/j.coi.2026.102739. Online ahead of print.<\/p>\n

ABSTRACT<\/b><\/p>\n

Sj\u00f6gren’s disease (SjD) is a chronic, systemic autoimmune disease that mainly targets saliva- and tear-producing glands. T-cells are a substantial immune cell subset involved in SjD pathogenesis, including break of tolerance toward self, and constitute a major part of tissue-resident and infiltrating immune cells in salivary glands (SGs) of patients with SjD. CD4+<\/sup> T-cells provide help to B-cells, thereby contributing to B-cell hyperactivity in this disease. Yet, interactions between T-cells and non-immune cells, including epithelial cells and fibroblasts, and how such interactions contribute to the dysfunction of the glands are incompletely understood. Although CD4\u207a T helper cells have long been a major focus of research due to their dominance within inflammatory foci and their role in B-cell differentiation, growing evidence also implicates CD8\u207a T-cells in pathogenic processes within SG tissue. In this review, novel findings regarding the role of T-cells in SjD pathogenesis are discussed, focusing on their phenotype and function in SGs. Furthermore, treatments targeting T-cells directly or indirectly that have demonstrated clinical efficacy in SjD are reviewed. Studying the impact of these treatments on T-cells may shed new light on their role in SjD pathogenesis.<\/p>\n

PMID:41702206<\/a> | DOI:10.1016\/j.coi.2026.102739<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Curr Opin Immunol. 2026 Feb 16;99:102739. doi: 10.1016\/j.coi.2026.102739. Online ahead of print. ABSTRACT Sj\u00f6gren’s disease (SjD) is a chronic, systemic autoimmune disease that mainly targets saliva- and tear-producing glands. T-cells are a substantial immune cell subset involved in SjD pathogenesis, including break of tolerance toward self, and constitute a major part of tissue-resident and infiltrating … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[59,42],"tags":[],"class_list":["post-56488","post","type-post","status-publish","format-standard","hentry","category-current-opinion-in-immunology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/56488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=56488"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/56488\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=56488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=56488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=56488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}