{"id":57193,"date":"2026-02-27T12:29:16","date_gmt":"2026-02-27T11:29:16","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/02\/27\/class-a-scavenger-receptors-promote-tumor-progression-and-induce-a-unique-macrophage-phenotype-in-a-mouse-model-of-spontaneous-breast-cancerbehjatolah-monzavi-karbassi-on-27-de-february-de\/"},"modified":"2026-02-27T12:29:16","modified_gmt":"2026-02-27T11:29:16","slug":"class-a-scavenger-receptors-promote-tumor-progression-and-induce-a-unique-macrophage-phenotype-in-a-mouse-model-of-spontaneous-breast-cancerbehjatolah-monzavi-karbassi-on-27-de-february-de","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/02\/27\/class-a-scavenger-receptors-promote-tumor-progression-and-induce-a-unique-macrophage-phenotype-in-a-mouse-model-of-spontaneous-breast-cancerbehjatolah-monzavi-karbassi-on-27-de-february-de\/","title":{"rendered":"Class A Scavenger receptors promote tumor progression and induce a unique macrophage phenotype in a mouse model of spontaneous breast cancer\u200bBehjatolah Monzavi-Karbassi on 27 de February de 2026 at 11:00"},"content":{"rendered":"
\n

J Leukoc Biol<\/b>. 2026 Feb 26:qiag026. doi: 10.1093\/jleuko\/qiag026. Online ahead of print.<\/p>\n

ABSTRACT<\/b><\/p>\n

Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A Scavenger Receptors (SR-A), which are pivotal in regulating macrophage activation and polarization into distinct phenotypes. SR-A expression is generally correlated with altered cytokine expression indicative of a tumor-supportive M2 macrophage phenotype. While evidence links an increased prevalence of SR-A-expressing TAMs to worse patient outcomes in breast cancer, a definitive role for SR-A and its potential ligands in cancer remains to be fully established. We previously reported that the fibroblast-activated proteinase (FAP)-cleaved collagen is a ligand for SR-A. This study was conducted to assess the role of FAP and SR-A expression in breast cancer. Using mouse models of spontaneous breast cancer, we found that the absence of SR-A, but not FAP, expression significantly delayed the development of palpable tumors and decreased the number of lung metastases in tumor-bearing mice. A soluble SR-A protein was used to demonstrate that SR-A binds to glycans on the surface of breast cancer cells. We used single-cell RNA sequencing and flow cytometry of isolated TAMs and identified a distinct SR-A-dependent TAM subpopulation characterized by high arginase 1 (Arg1) gene expression. Pathway analysis of TAMs associates SR-A expression with activation of transcriptional programs linked to immune-suppressive macrophage phenotypes. These results define a contributory role for SR-A in breast cancer progression and provide new insights into the complex interactions between TAMs and cancer cells in the tumor microenvironment.<\/p>\n

PMID:41749430<\/a> | DOI:10.1093\/jleuko\/qiag026<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Leukoc Biol. 2026 Feb 26:qiag026. doi: 10.1093\/jleuko\/qiag026. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A Scavenger Receptors (SR-A), which are pivotal in regulating macrophage activation and polarization into … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[86,42],"tags":[],"class_list":["post-57193","post","type-post","status-publish","format-standard","hentry","category-journal-of-leukocyte-biology","category-publicaciones"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=57193"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57193\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=57193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=57193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=57193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}