{"id":57250,"date":"2026-03-02T02:20:21","date_gmt":"2026-03-02T01:20:21","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/t-cells-co-expressing-high-levels-of-cd29-and-cd99-show-increased-cytotoxic-potential-and-are-upregulated-in-sjogrens-disease\/"},"modified":"2026-03-02T02:20:21","modified_gmt":"2026-03-02T01:20:21","slug":"t-cells-co-expressing-high-levels-of-cd29-and-cd99-show-increased-cytotoxic-potential-and-are-upregulated-in-sjogrens-disease","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/t-cells-co-expressing-high-levels-of-cd29-and-cd99-show-increased-cytotoxic-potential-and-are-upregulated-in-sjogrens-disease\/","title":{"rendered":"T cells co-expressing high levels of CD29 and CD99 show increased cytotoxic potential and are upregulated in Sj\u00f6gren’s disease"},"content":{"rendered":"
\n

J Immunol<\/b>. 2026 Feb 9;215(2):vkaf370. doi: 10.1093\/jimmun\/vkaf370.<\/p>\n

ABSTRACT<\/b><\/p>\n

This study aimed to investigate the role of CD29 and CD99 in human T lymphocytes and elucidate its significance in Sj\u00f6gren’s disease (SjD). ScRNA-Seq data were utilized to analyze CD29 and CD99 expression in PBMCs. CD29 and CD99-expressing T lymphocyte proportions in SjD patients and healthy controls were determined by flow cytometry. Bulk RNA-Seq was performed to identify differential gene expression between the CD29hiCD99hi and CD29intCD99int subsets. The roles of CD29 and CD99 were elucidated through the stimulation of T lymphocytes with anti-CD29 and anti-CD99. CD29 and CD99-related subsets were analyzed in SjD patients, and their clinical value was determined using ROC curves. ScRNA-Seq data uncovered a strong positive correlation between CD29 and CD99 in both CD4+ and CD8+ T cells. Flow cytometry confirmed their co-expression, categorizing T cells into CD29intCD99int and CD29hiCD99hi groups. CD29hiCD99hi T cells exhibited high expression of cytotoxic molecules, and displayed activation features, with higher levels of Ki-67, PD-1, and CD25. Stimulation with anti-CD99 and anti-CD29 increased granzyme B levels in CD29hiCD99hi CD8+ T cells. CD29hiCD99hi CD8+ T cells were significantly elevated in SjD. However, ROC analysis indicated that only TIGIT expression in CD29hiCD99hiCD4+ T cells achieved a high AUC value. In conclusion, CD29 and CD99 exhibited significant co-expression in peripheral T cells, while CD29hiCD99hi T cells exhibit increased expression of molecules associated with cytotoxicity and an activated phenotype. The alterations in CD29hiCD99hi T cell subsets among SjD patients may contribute to the early identification of SjD and warrant further longitudinal investigation.<\/p>\n

PMID:41764742<\/a> | DOI:10.1093\/jimmun\/vkaf370<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

J Immunol. 2026 Feb 9;215(2):vkaf370. doi: 10.1093\/jimmun\/vkaf370. ABSTRACT This study aimed to investigate the role of CD29 and CD99 in human T lymphocytes and elucidate its significance in Sj\u00f6gren’s disease (SjD). ScRNA-Seq data were utilized to analyze CD29 and CD99 expression in PBMCs. CD29 and CD99-expressing T lymphocyte proportions in SjD patients and healthy controls … Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-57250","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=57250"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57250\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=57250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=57250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=57250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}