{"id":57256,"date":"2026-03-02T02:20:22","date_gmt":"2026-03-02T01:20:22","guid":{"rendered":"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/mll1-directs-gut-associated-antibody-responses-to-helminth-and-bacterial-infections\/"},"modified":"2026-03-02T02:20:22","modified_gmt":"2026-03-02T01:20:22","slug":"mll1-directs-gut-associated-antibody-responses-to-helminth-and-bacterial-infections","status":"publish","type":"post","link":"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/mll1-directs-gut-associated-antibody-responses-to-helminth-and-bacterial-infections\/","title":{"rendered":"MLL1 directs gut-associated antibody responses to helminth and bacterial infections"},"content":{"rendered":"<div>\n<p><b>J Immunol<\/b>. 2026 Feb 9;215(2):vkaf358. doi: 10.1093\/jimmun\/vkaf358.<\/p>\n<p><b>ABSTRACT<\/b><\/p>\n<p>Soil-transmitted helminths are one of the most common infections globally, yet how to promote effective gut-associated humoral responses is not well understood. We identify the histone methyltransferase MLL1 as a key target to promote IgA-driven responses. Mll1 was increased in germinal center B cells in gut-associated lymphoid tissues, and Mll1-deficiency led to changes in the histone modification H3K4me3 on key B cell and immune-regulatory genes. Correspondingly, MLL1-deficient B cells had defective germinal centers and IgG1 in response to the helminth Trichuris muris. Yet Mll1f\/fCd23cre\/+ mice expelled worms more rapidly compared to control mice. Accelerated worm clearance correlated with elevated immunoglobulin A (IgA)+ plasma cells, as well as both serum and fecal IgA. RNA-sequencing identified CCR9 as a key MLL1-regulated molecule. As such, Mll1f\/fCd23cre\/+ mice infected with T. muris had increased IgA+CCR9+ PC localized in the large intestine. Regulation of IgA by MLL1 was confirmed beyond T. muris infection. In vitro cultures confirmed Mll1-deficiency increased IgA+ plasma cells in a B cell-intrinsic manner, and IgA production was also increased in Mll1f\/fCd23cre\/+ mice infected with the bacterium Citrobacter rodentium. This study reveals MLL1 as a key target to promote IgA responses to gut-associated infections.<\/p>\n<p>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41764736\/?utm_source=SimplePie&amp;utm_medium=rss&amp;utm_content=2985117R&amp;ff=20260301202012&amp;v=2.19.0.post6+133c1fe\">41764736<\/a> | DOI:<a href=\"https:\/\/doi.org\/10.1093\/jimmun\/vkaf358\">10.1093\/jimmun\/vkaf358<\/a><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>J Immunol. 2026 Feb 9;215(2):vkaf358. doi: 10.1093\/jimmun\/vkaf358. ABSTRACT Soil-transmitted helminths are one of the most common infections globally, yet how to promote effective gut-associated humoral responses is not well understood. We identify the histone methyltransferase MLL1 as a key target to promote IgA-driven responses. Mll1 was increased in germinal center B cells in gut-associated lymphoid &#8230; <a title=\"MLL1 directs gut-associated antibody responses to helminth and bacterial infections\" class=\"read-more\" href=\"https:\/\/inmuno.es\/index.php\/2026\/03\/02\/mll1-directs-gut-associated-antibody-responses-to-helminth-and-bacterial-infections\/\" aria-label=\"Read more about MLL1 directs gut-associated antibody responses to helminth and bacterial infections\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42,71],"tags":[],"class_list":["post-57256","post","type-post","status-publish","format-standard","hentry","category-publicaciones","category-the-journal-of-immunology"],"_links":{"self":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/comments?post=57256"}],"version-history":[{"count":0,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/posts\/57256\/revisions"}],"wp:attachment":[{"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/media?parent=57256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/categories?post=57256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/inmuno.es\/index.php\/wp-json\/wp\/v2\/tags?post=57256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}